TUBB2A

From Wikipedia, the free encyclopedia

Tubulin, beta 2A

PDB rendering based on 1ffx.

Available structures: 1ffx, 1ia0, 1jff, 1sa0, 1sa1, 1tub, 1tvk, 1z2b, 2hxf, 2hxh

Identifiers

Symbol(s)

TUBB2A; TUBB; TUBB2; dJ40E16.7

External IDs

MGI: 107861 HomoloGene: 68156

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • structural constituent of cytoskeleton • GTP binding
Cellular Component:	• cytoplasm • cytoskeleton • microtubule • protein complex
Biological Process:	• microtubule-based movement • protein polymerization

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001069 (mRNA)
NP_001060 (protein)

NM_009450 (mRNA)
NP_033476 (protein)

Location

Chr 6: 3.1 - 3.1 Mb

Chr 13: 34.08 - 34.09 Mb

Pubmed search

[1]

[2]

Tubulin, beta 2A, also known as TUBB2A, is a human gene.^[1]

[edit] References

^ Entrez Gene: TUBB2A tubulin, beta 2A.

[edit] Further reading

Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.". J. Infect. 24 (3): 317-20. PMID 1602151.
Horisberger MA (1992). "Interferon-induced human protein MxA is a GTPase which binds transiently to cellular proteins.". J. Virol. 66 (8): 4705-9. PMID 1629950.
Wang D, Villasante A, Lewis SA, Cowan NJ (1987). "The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype.". J. Cell Biol. 103 (5): 1903-10. PMID 3782288.
Lee MG, Lewis SA, Wilde CD, Cowan NJ (1983). "Evolutionary history of a multigene family: an expressed human beta-tubulin gene and three processed pseudogenes.". Cell 33 (2): 477-87. PMID 6688039.
Takahashi M, Tomizawa K, Sato K, et al. (1995). "A novel tau-tubulin kinase from bovine brain.". FEBS Lett. 372 (1): 59-64. PMID 7556643.
Yamaguchi N, Fukuda MN (1995). "Golgi retention mechanism of beta-1,4-galactosyltransferase. Membrane-spanning domain-dependent homodimerization and association with alpha- and beta-tubulins.". J. Biol. Chem. 270 (20): 12170-6. PMID 7744867.
Waterman-Storer CM, Karki S, Holzbaur EL (1995). "The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1).". Proc. Natl. Acad. Sci. U.S.A. 92 (5): 1634-8. PMID 7878030.
Carr D, Knull H (1993). "Aldolase-tubulin interactions: removal of tubulin C-terminals impairs interactions.". Biochem. Biophys. Res. Commun. 195 (1): 289-93. doi:10.1006/bbrc.1993.2043. PMID 8103323.
Volz A, Weiss E, Trowsdale J, Ziegler A (1994). "Presence of an expressed beta-tubulin gene (TUBB) in the HLA class I region may provide the genetic basis for HLA-linked microtubule dysfunction.". Hum. Genet. 93 (1): 42-6. PMID 8270253.
Paschal BM, Holzbaur EL, Pfister KK, et al. (1993). "Characterization of a 50-kDa polypeptide in cytoplasmic dynein preparations reveals a complex with p150GLUED and a novel actin.". J. Biol. Chem. 268 (20): 15318-23. PMID 8325901.
Linhartová I, Dráberová E, Viklický V, Dráber P (1993). "Distribution of non-class-III beta-tubulin isoforms in neuronal and non-neuronal cells.". FEBS Lett. 320 (1): 79-82. PMID 8462682.
Huby RD, Carlile GW, Ley SC (1996). "Interactions between the protein-tyrosine kinase ZAP-70, the proto-oncoprotein Vav, and tubulin in Jurkat T cells.". J. Biol. Chem. 270 (51): 30241-4. PMID 8530437.
Bosc C, Cronk JD, Pirollet F, et al. (1996). "Cloning, expression, and properties of the microtubule-stabilizing protein STOP.". Proc. Natl. Acad. Sci. U.S.A. 93 (5): 2125-30. PMID 8700896.
Tian G, Huang Y, Rommelaere H, et al. (1996). "Pathway leading to correctly folded beta-tubulin.". Cell 86 (2): 287-96. PMID 8706133.
Tokito MK, Howland DS, Lee VM, Holzbaur EL (1997). "Functionally distinct isoforms of dynactin are expressed in human neurons.". Mol. Biol. Cell 7 (8): 1167-80. PMID 8856662.
Kinnunen T, Kaksonen M, Saarinen J, et al. (1998). "Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth.". J. Biol. Chem. 273 (17): 10702-8. PMID 9553134.
Niethammer M, Valtschanoff JG, Kapoor TM, et al. (1998). "CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90.". Neuron 20 (4): 693-707. PMID 9581762.
Rasmussen RK, Ji H, Eddes JS, et al. (1998). "Two-dimensional electrophoretic analysis of mixed lineage kinase 2 N-terminal domain binding proteins.". Electrophoresis 19 (5): 809-17. doi:10.1002/elps.1150190535. PMID 9629920.
Ciruela F, Robbins MJ, Willis AC, McIlhinney RA (1999). "Interactions of the C terminus of metabotropic glutamate receptor type 1alpha with rat brain proteins: evidence for a direct interaction with tubulin.". J. Neurochem. 72 (1): 346-54. PMID 9886087.
Chau MF, Radeke MJ, de Inés C, et al. (1999). "The microtubule-associated protein tau cross-links to two distinct sites on each alpha and beta tubulin monomer via separate domains.". Biochemistry 37 (51): 17692-703. PMID 9922135.