TUBB1

From Wikipedia, the free encyclopedia

Tubulin, beta 1

Identifiers

TUBB1; dJ543J19.4

External IDs

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • structural molecule activity • GTP binding
Cellular Component:	• microtubule • protein complex
Biological Process:	• microtubule-based movement • protein polymerization

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_030773 (mRNA)
NP_110400 (protein)

XM_619851 (mRNA)
XP_619851 (protein)

Location

Chr 20: 57.03 - 57.04 Mb

n/a

Pubmed search

[1]

[2]

Tubulin, beta 1, also known as TUBB1, is a human gene.^[1]

[edit] References

^ Entrez Gene: TUBB1 tubulin, beta 1.

[edit] Further reading

Watts NR, Sackett DL, Ward RD, et al. (2000). "HIV-1 rev depolymerizes microtubules to form stable bilayered rings.". J. Cell Biol. 150 (2): 349-60. PMID 10908577.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1-11. PMID 11790298.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Chen D, Wang M, Zhou S, Zhou Q (2004). "HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim.". EMBO J. 21 (24): 6801-10. PMID 12486001.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566-9. doi:10.1038/nbt810. PMID 12665801.
Yanagida M, Hayano T, Yamauchi Y, et al. (2004). "Human fibrillarin forms a sub-complex with splicing factor 2-associated p32, protein arginine methyltransferases, and tubulins alpha 3 and beta 1 that is independent of its association with preribosomal ribonucleoprotein complexes.". J. Biol. Chem. 279 (3): 1607-14. doi:10.1074/jbc.M305604200. PMID 14583623.
Dou Z, Ding X, Zereshki A, et al. (2004). "TTK kinase is essential for the centrosomal localization of TACC2.". FEBS Lett. 572 (1-3): 51-6. doi:10.1016/j.febslet.2004.06.092. PMID 15304323.
Schulze H, Korpal M, Bergmeier W, et al. (2005). "Interactions between the megakaryocyte/platelet-specific beta1 tubulin and the secretory leukocyte protease inhibitor SLPI suggest a role for regulated proteolysis in platelet functions.". Blood 104 (13): 3949-57. doi:10.1182/blood-2004-03-1179. PMID 15315966.
Campbell GR, Pasquier E, Watkins J, et al. (2005). "The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis.". J. Biol. Chem. 279 (46): 48197-204. doi:10.1074/jbc.M406195200. PMID 15331610.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
de Mareuil J, Carre M, Barbier P, et al. (2006). "HIV-1 Tat protein enhances microtubule polymerization.". Retrovirology 2: 5. doi:10.1186/1742-4690-2-5. PMID 15691386.
Giacca M (2006). "HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?". Retrovirology 2: 7. doi:10.1186/1742-4690-2-7. PMID 15698476.
Freson K, De Vos R, Wittevrongel C, et al. (2005). "The TUBB1 Q43P functional polymorphism reduces the risk of cardiovascular disease in men by modulating platelet function and structure.". Blood 106 (7): 2356-62. doi:10.1182/blood-2005-02-0723. PMID 15956286.
Mesquita B, Veiga I, Pereira D, et al. (2006). "No significant role for beta tubulin mutations and mismatch repair defects in ovarian cancer resistance to paclitaxel/cisplatin.". BMC Cancer 5: 101. doi:10.1186/1471-2407-5-101. PMID 16095531.
Coiras M, Camafeita E, Ureña T, et al.. "Modifications in the human T cell proteome induced by intracellular HIV-1 Tat protein expression.". Proteomics 6 Suppl 1: S63-73. doi:10.1002/pmic.200500437. PMID 16526095.
Navarro-Núñez L, Lozano ML, Rivera J, et al. (2007). "The association of the beta1-tubulin Q43P polymorphism with intracerebral hemorrhage in men.". Haematologica 92 (4): 513-8. PMID 17488662.