TTF2

From Wikipedia, the free encyclopedia

Transcription termination factor, RNA polymerase II

Identifiers

TTF2; HuF2

External IDs

OMIM: 604718 MGI: 1921294 HomoloGene: 37826

Gene ontology
Molecular Function:	• nucleotide binding • DNA binding • RNA polymerase II transcription termination factor activity • ATP binding • ATP-dependent helicase activity • DNA-dependent ATPase activity • zinc ion binding • hydrolase activity
Cellular Component:	• nucleus • spliceosome • transcription elongation factor complex
Biological Process:	• transcription • transcription termination • regulation of transcription, DNA-dependent • mRNA processing • RNA splicing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003594 (mRNA)
NP_003585 (protein)

NM_001013026 (mRNA)
NP_001013044 (protein)

Location

Chr 1: 117.4 - 117.45 Mb

Chr 3: 101.07 - 101.1 Mb

Pubmed search

[1]

[2]

Transcription termination factor, RNA polymerase II, also known as TTF2, is a human gene.^[1]

This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing.^[1]

[edit] References

^ ^a ^b Entrez Gene: TTF2 transcription termination factor, RNA polymerase II.

[edit] Further reading

Girdham CH, Glover DM (1991). "Chromosome tangling and breakage at anaphase result from mutations in lodestar, a Drosophila gene encoding a putative nucleoside triphosphate-binding protein.". Genes Dev. 5 (10): 1786–99. PMID 1916263.
Liu M, Xie Z, Price DH (1998). "A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member.". J. Biol. Chem. 273 (40): 25541–4. PMID 9748214.
Hara R, Selby CP, Liu M, et al. (1999). "Human transcription release factor 2 dissociates RNA polymerases I and II stalled at a cyclobutane thymine dimer.". J. Biol. Chem. 274 (35): 24779–86. PMID 10455150.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Leonard D, Ajuh P, Lamond AI, Legerski RJ (2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing.". Biochem. Biophys. Res. Commun. 308 (4): 793–801. PMID 12927788.
Jiang Y, Liu M, Spencer CA, Price DH (2004). "Involvement of transcription termination factor 2 in mitotic repression of transcription elongation.". Mol. Cell 14 (3): 375–85. PMID 15125840.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Jiang Y, Price DH (2006). "Rescue of the TTF2 knockdown phenotype with an siRNA-resistant replacement vector.". Cell Cycle 3 (9): 1151–3. PMID 15467445.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.