TSEN2

From Wikipedia, the free encyclopedia

TRNA splicing endonuclease 2 homolog (S. cerevisiae)

Identifiers

TSEN2; SEN2; MGC2776; MGC4440; SEN2L

External IDs

OMIM: 608753 MGI: 2141599 HomoloGene: 41622

Gene ontology
Molecular Function:	• tRNA-intron endonuclease activity • endonuclease activity • hydrolase activity
Cellular Component:	• tRNA-intron endonuclease complex • nucleus
Biological Process:	• tRNA splicing • mRNA processing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_025265 (mRNA)
NP_079541 (protein)

NM_199033 (mRNA)
NP_950198 (protein)

Location

Chr 3: 12.5 - 12.56 Mb

Chr 6: 115.51 - 115.54 Mb

Pubmed search

[1]

[2]

TRNA splicing endonuclease 2 homolog (S. cerevisiae), also known as TSEN2, is a human gene.^[1]

tRNA splicing is a fundamental process required for cell growth and division. SEN2 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: TSEN2 tRNA splicing endonuclease 2 homolog (S. cerevisiae).

[edit] Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093-101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Paushkin SV, Patel M, Furia BS, et al. (2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation.". Cell 117 (3): 311-21. PMID 15109492.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773-84. doi:10.1101/gr.406902. PMID 12421765.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.