Tryptophan 2-C-methyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a tryptophan 2-C-methyltransferase (EC 2.1.1.106) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + L-tryptophan S-adenosyl-L-homocysteine + L-2-methyltryptophan

Thus, the two substrates of this enzyme are S-adenosyl methionine and L-tryptophan, whereas its two products are S-adenosylhomocysteine and L-2-methyltryptophan.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:L-tryptophan 2-C-methyltransferase. Other names in common use include tryptophan 2-methyltransferase, and S-adenosylmethionine:tryptophan 2-methyltransferase.

[edit] References

• IUBMB entry for 2.1.1.106
• BRENDA references for 2.1.1.106 (Recommended.)
• PubMed references for 2.1.1.106
• PubMed Central references for 2.1.1.106
• Google Scholar references for 2.1.1.106
• Frenzel T, Zhou P, Floss HG (1990). "Formation of 2-methyltryptophan in the biosynthesis of thiostrepton: isolation of S-adenosylmethionine:tryptophan 2-methyltransferase". Arch. Biochem. Biophys. 278: 35–40. PMID 2321967. 

[edit] External links

The CAS registry number for this enzyme class is 126626-83-3.

• IUBMB entry for 2.1.1.106

• KEGG entry for 2.1.1.106

• BRENDA entry for 2.1.1.106

• NiceZyme view of 2.1.1.106

• EC2PDB: PDB structures for 2.1.1.106

• PRIAM entry for 2.1.1.106

• PUMA2 entry for 2.1.1.106

• IntEnz: Integrated Enzyme entry for 2.1.1.106

• MetaCyc entry for 2.1.1.106

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0030772: tryptophan 2-C-methyltransferase

• AMIGO entry for GO code 0030772: tryptophan 2-C-methyltransferase