TRNT1

From Wikipedia, the free encyclopedia

TRNA nucleotidyl transferase, CCA-adding, 1

PDB rendering based on 1ou5.

Available structures: 1ou5

Identifiers

Symbol(s)

TRNT1; CCA1; CGI-47; MtCCA

External IDs

MGI: 1917297 HomoloGene: 9333

Gene ontology
Molecular Function:	• tRNA binding • nucleotide binding • magnesium ion binding • tRNA adenylyltransferase activity • ATP binding • transferase activity
Cellular Component:	• intracellular • mitochondrion
Biological Process:	• protein targeting to mitochondrion • tRNA 3'-processing

Orthologs

Human

Mouse

Refseq

NM_016000 (mRNA)
NP_057084 (protein)

NM_027296 (mRNA)
NP_081572 (protein)

Location

Chr 3: 3.14 - 3.17 Mb

Chr 6: 106.73 - 106.75 Mb

Pubmed search

[1]

[2]

TRNA nucleotidyl transferase, CCA-adding, 1, also known as TRNT1, is a human gene.^[1]

[edit] References

^ Entrez Gene: TRNT1 tRNA nucleotidyl transferase, CCA-adding, 1.

[edit] Further reading

Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703–13. PMID 10810093.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Nagaike T, Suzuki T, Tomari Y, et al. (2001). "Identification and characterization of mammalian mitochondrial tRNA nucleotidyltransferases.". J. Biol. Chem. 276 (43): 40041–9. doi:10.1074/jbc.M106202200. PMID 11504732.
Reichert AS, Thurlow DL, Mörl M (2002). "A eubacterial origin for the human tRNA nucleotidyltransferase?". Biol. Chem. 382 (10): 1431–8. PMID 11727826.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Augustin MA, Reichert AS, Betat H, et al. (2003). "Crystal structure of the human CCA-adding enzyme: insights into template-independent polymerization.". J. Mol. Biol. 328 (5): 985–94. PMID 12729736.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
Lizano E, Schuster J, Müller M, et al. (2007). "A splice variant of the human CCA-adding enzyme with modified activity.". J. Mol. Biol. 366 (4): 1258–65. doi:10.1016/j.jmb.2006.12.016. PMID 17204286.