tRNA (adenine-N6-)-methyltransferase

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In enzymology, a tRNA (adenine-N6-)-methyltransferase (EC 2.1.1.55) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + tRNA $\rightleftharpoons$ S-adenosyl-L-homocysteine + tRNA containing N₆-methyladenine

Thus, the two substrates of this enzyme are S-adenosyl methionine and tRNA, whereas its two products are S-adenosylhomocysteine and tRNA containing N6-methyladenine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:tRNA (adenine-N6-)-methyltransferase. This enzyme is also called S-adenosyl-L-methionine:tRNA (adenine-6-N-)-methyltransferase.

[edit] References

IUBMB entry for 2.1.1.55
BRENDA references for 2.1.1.55 (Recommended.)
PubMed references for 2.1.1.55
PubMed Central references for 2.1.1.55
Google Scholar references for 2.1.1.55
Mandel LR, Hacker B, Maag TA (1971). "Altered transfer RNA methylase patterns in Marek's disease tumors". Cancer. Res. 31: 613–6. PMID 4996578.
Mittelman A, Hall RH, Yohn DS, Grace JT Jr (1967). "The in vitro soluble RNA methylase activity of SV40-induced hamster tumors". Cancer. Res. 27: 1409–14. PMID 4292682.
Sharma OK (1973). "Differences in the transfer RNA methyltransferases from normal rat liver and Novikoff hepatoma". Biochim. Biophys. Acta. 299: 415–27. PMID 4349332.