tRNA (adenine-N1-)-methyltransferase

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In enzymology, a tRNA (adenine-N1-)-methyltransferase (EC 2.1.1.36) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + tRNA $\rightleftharpoons$ S-adenosyl-L-homocysteine + tRNA containing N₁-methyladenine

Thus, the two substrates of this enzyme are S-adenosyl methionine and tRNA, whereas its two products are S-adenosylhomocysteine and tRNA containing N1-methyladenine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:tRNA (adenine-N1-)-methyltransferase. Other names in common use include transfer ribonucleate adenine 1-methyltransferase, transfer RNA (adenine-1) methyltransferase, 1-methyladenine transfer RNA methyltransferase, adenine-1-methylase, and S-adenosyl-L-methionine:tRNA (adenine-1-N-)-methyltransferase.

[edit] References

IUBMB entry for 2.1.1.36
BRENDA references for 2.1.1.36 (Recommended.)
PubMed references for 2.1.1.36
PubMed Central references for 2.1.1.36
Google Scholar references for 2.1.1.36
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Glick JM, Leboy PS (1977). "Purification and properties of tRNA(adenine-1)-methyltransferase from rat liver". J. Biol. Chem. 252: 4790–5. PMID 17605.