tRNA-pseudouridine synthase I

From Wikipedia, the free encyclopedia

In enzymology, a tRNA-pseudouridine synthase I (EC 5.4.99.12) is an enzyme that catalyzes the chemical reaction

tRNA uridine $\rightleftharpoons$ tRNA pseudouridine

Hence, this enzyme has one substrate, tRNA uridine, and one product, tRNA pseudouridine.

This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. The systematic name of this enzyme class is tRNA-uridine uracilmutase. Other names in common use include tRNA-uridine isomerase, tRNA pseudouridylate synthase I, transfer ribonucleate pseudouridine synthetase, pseudouridine synthase, and transfer RNA pseudouridine synthetase.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1VS3, 2NQP, 2NR0, and 2NRE.

[edit] References

IUBMB entry for 5.4.99.12
BRENDA references for 5.4.99.12 (Recommended.)
PubMed references for 5.4.99.12
PubMed Central references for 5.4.99.12
Google Scholar references for 5.4.99.12
Arena F, Ciliberto G, Ciampi S, Cortese R (1978). "Purification of pseudouridylate synthetase I from Salmonella typhimurium". Nucleic. Acids. Res. 5: 4523–36. doi:10.1093/nar/5.12.4523. PMID 370771.
Kammen HO, Marvel CC, Hardy L, Penhoet EE (1988). "Purification, structure, and properties of Escherichia coli tRNA pseudouridine synthase I". J. Biol. Chem. 263: 2255–63. PMID 3276686.