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| TrkB IRES |
 |
| Type: |
Cis-reg; IRES; |
| 2° structure: |
Predicted; RNAFOLD; |
| Seed alignment: |
PubMed |
| Avg length: |
352.6 nucleotides |
| Avg identity: |
98% |
|
The TrkB internal ribosome entry site (IRES) is an RNA element which is present in the 5' UTR sequence of the mRNA. TrkB is a neurotrophin receptor which is essential for the development and maintenance of the nervous system. The internal ribosome entry site IRES element allows cap-independent translation of TrkB which may be needed for efficient translation in neuronal dendrites.[1]
[edit] References
- ^ Dobson, T; Minic A, Nielsen K, Amiott E, Krushel L (2005). "Internal initiation of translation of the TrkB mRNA is mediated by multiple regions within the 5' leader". Nucleic Acids Res 33: 2929–2941. doi:10.1093/nar/gki605. PMID 15908588.
[edit] External links
