Triphosphate-protein phosphotransferase

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In enzymology, a triphosphate-protein phosphotransferase (EC 2.7.99.1) is an enzyme that catalyzes the chemical reaction

triphosphate + [microsomal-membrane protein] $\rightleftharpoons$ diphosphate + phospho-[microsomal-membrane protein]

Thus, the two substrates of this enzyme are triphosphate and microsomal-membrane protein, whereas its two products are diphosphate and [[phospho-[microsomal-membrane protein]]].

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups that are not covered by other phosphotransferase families. The systematic name of this enzyme class is triphosphate:[microsomal-membrane-protein] phosphotransferase. Other names in common use include diphosphate:microsomal-membrane-protein O-phosphotransferase, (erroneous), DiPPT (erroneous), pyrophosphate:protein phosphotransferase (erroneous), diphosphate-protein phosphotransferase (erroneous), diphosphate:[microsomal-membrane-protein] O-phosphotransferase, and (erroneous).

[edit] References

IUBMB entry for 2.7.99.1
BRENDA references for 2.7.99.1 (Recommended.)
PubMed references for 2.7.99.1
PubMed Central references for 2.7.99.1
Google Scholar references for 2.7.99.1
Lam KS, Kasper CB (1980). "Pyrophosphate:protein phosphotransferase: a membrane-bound enzyme of endoplasmic reticulum". Proc. Natl. Acad. Sci. U. S. A. 77: 1927–31. doi:10.1073/pnas.77.4.1927. PMID 6246514.
Tsutsui K (1986). "Tripolyphosphate is an alternative phosphodonor of the selective protein phosphorylation of liver microsomal membrane". J. Biol. Chem. 261: 2645–53. PMID 3949741.