Trimetrexate
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Trimetrexate
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| Systematic (IUPAC) name | |
| 5-methyl-6-[(3,4,5-trimethoxyphenyl) aminomethyl] quinazoline-2,4-diamine | |
| Identifiers | |
| CAS number | |
| ATC code | P01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C19H23N5O3 |
| Mol. mass | 369.418 g/mol |
| Pharmacokinetic data | |
| Bioavailability | VD: 20-30 Liters |
| Metabolism | Oxidative O-demethylation, followed by conjugation with glucuronide or sulfate |
| Half life | 11 to 12 hours |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | ? |
Trimetrexate is a quinazoline derivative and dihydrofolate reductase inhibitor used with leucovorin in treating pneumocystis pneumonia.
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