Trimethylsulfonium-tetrahydrofolate N-methyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a trimethylsulfonium-tetrahydrofolate N-methyltransferase (EC 2.1.1.19) is an enzyme that catalyzes the chemical reaction

trimethylsulfonium + tetrahydrofolate dimethylsulfide + 5-methyltetrahydrofolate

Thus, the two substrates of this enzyme are trimethylsulfonium and tetrahydrofolate, whereas its two products are dimethyl sulfide and 5-methyltetrahydrofolate.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is trimethylsulfonium:tetrahydrofolate N-methyltransferase. This enzyme is also called trimethylsulfonium-tetrahydrofolate methyltransferase. This enzyme participates in one carbon pool by folate.

[edit] References

• IUBMB entry for 2.1.1.19
• BRENDA references for 2.1.1.19 (Recommended.)
• PubMed references for 2.1.1.19
• PubMed Central references for 2.1.1.19
• Google Scholar references for 2.1.1.19
• Wagner C, Lusty SM Jr, Kung HF, Rogers NL (1967). "Preparation and properties of trimethylsulfonium-tetrahydrofolate methyltransferase". J. Biol. Chem. 242: 1287–93. PMID 6023571. 

[edit] External links

The CAS registry number for this enzyme class is 37256-92-1.

• IUBMB entry for 2.1.1.19

• KEGG entry for 2.1.1.19

• BRENDA entry for 2.1.1.19

• NiceZyme view of 2.1.1.19

• EC2PDB: PDB structures for 2.1.1.19

• PRIAM entry for 2.1.1.19

• PUMA2 entry for 2.1.1.19

• IntEnz: Integrated Enzyme entry for 2.1.1.19

• MetaCyc entry for 2.1.1.19

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047147: trimethylsulfonium-tetrahydrofolate N-methyltransferase

• AMIGO entry for GO code 0047147: trimethylsulfonium-tetrahydrofolate N-methyltransferase