Trimethylamine dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a trimethylamine dehydrogenase (EC 1.5.8.2) is an enzyme that catalyzes the chemical reaction

trimethylamine + H₂O + electron-transferring flavoprotein dimethylamine + formaldehyde + reduced electron-transferring flavoprotein

The 3 substrates of this enzyme are trimethylamine, H₂O, and electron-transferring flavoprotein, whereas its 3 products are dimethylamine, formaldehyde, and reduced electron-transferring flavoprotein.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with a flavin as acceptor. The systematic name of this enzyme class is trimethylamine:electron-transferring flavoprotein oxidoreductase (demethylating). This enzyme participates in methane metabolism.

[edit] References

• IUBMB entry for 1.5.8.2
• BRENDA references for 1.5.8.2 (Recommended.)
• PubMed references for 1.5.8.2
• PubMed Central references for 1.5.8.2
• Google Scholar references for 1.5.8.2
• Colby J and Zatman LJ (1971). "The purification and properties of a bacterial trimethylamine dehydrogenase". Biochem. J. 121: 9. 
• Steenkamp DJ, Singer TP (1978). "Participation of the iron-sulphur cluster and of the covalently bound coenzyme of trimethylamine dehydrogenase in catalysis". Biochem. J. 169: 361–9. PMID 204297. 
• Huang L, Rohlfs RJ, Hille R (1995). "The reaction of trimethylamine dehydrogenase with electron transferring flavoprotein". J. Biol. Chem. 270: 23958–65. doi:10.1074/jbc.270.41.23958. PMID 7592591. 
• MJ, Scrutton NS (2002). "Electron transfer and conformational change in complexes of trimethylamine dehydrogenase and electron transferring flavoprotein". J. Biol. Chem. 277: 8457–65. doi:10.1074/jbc.M111105200. PMID 11756429. 
• Scrutton NS, Sutcliffe MJ (2000). "Trimethylamine dehydrogenase and electron transferring flavoprotein". Subcell. Biochem. 35: 145–81. PMID 11192721. 

[edit] External links

The CAS registry number for this enzyme class is 39307-09-0.

• IUBMB entry for 1.5.8.2

• KEGG entry for 1.5.8.2

• BRENDA entry for 1.5.8.2

• NiceZyme view of 1.5.8.2

• EC2PDB: PDB structures for 1.5.8.2

• PRIAM entry for 1.5.8.2

• PUMA2 entry for 1.5.8.2

• IntEnz: Integrated Enzyme entry for 1.5.8.2

• MetaCyc entry for 1.5.8.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050470: trimethylamine dehydrogenase

• AMIGO entry for GO code 0050470: trimethylamine dehydrogenase