Trimethylamine-oxide aldolase

From Wikipedia, the free encyclopedia

In enzymology, a trimethylamine-oxide aldolase (EC 4.1.2.32) is an enzyme that catalyzes the chemical reaction

trimethylamine N-oxide dimethylamine + formaldehyde

Hence, this enzyme has one substrate, trimethylamine N-oxide, and two products, dimethylamine and formaldehyde.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is trimethylamine-N-oxide formaldehyde-lyase (dimethylamine-forming). Other names in common use include trimethylamine N-oxide formaldehyde-lyase, trimethylamine N-oxide aldolase, trimethylamine N-oxide demethylase, and trimethylamine-N-oxide formaldehyde-lyase. This enzyme participates in methane metabolism.

[edit] References

• IUBMB entry for 4.1.2.32
• BRENDA references for 4.1.2.32 (Recommended.)
• PubMed references for 4.1.2.32
• PubMed Central references for 4.1.2.32
• Google Scholar references for 4.1.2.32
• Large PJ (1971). "Non-oxidative demethylation of trimethylamine N-oxide by Pseudomonas aminovorans". FEBS. Lett. 18: 297–300. doi:10.1016/0014-5793(71)80470-2. PMID 11946146. 
• Myers PA, Zatman LJ (1971). "The metabolism of trimethylamine N-oxide by Bacillus PM6". Biochem. J. 121: 10P. PMID 5116524. 

[edit] External links

The CAS registry number for this enzyme class is 72561-08-1.

• IUBMB entry for 4.1.2.32

• KEGG entry for 4.1.2.32

• BRENDA entry for 4.1.2.32

• NiceZyme view of 4.1.2.32

• EC2PDB: PDB structures for 4.1.2.32

• PRIAM entry for 4.1.2.32

• PUMA2 entry for 4.1.2.32

• IntEnz: Integrated Enzyme entry for 4.1.2.32

• MetaCyc entry for 4.1.2.32

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050352: trimethylamine-oxide aldolase

• AMIGO entry for GO code 0050352: trimethylamine-oxide aldolase