Trichodiene synthase

From Wikipedia, the free encyclopedia

In enzymology, a trichodiene synthase (EC 4.2.3.6) is an enzyme that catalyzes the chemical reaction

trans,trans-farnesyl diphosphate trichodiene + diphosphate

Hence, this enzyme has one substrate, trans,trans-farnesyl diphosphate, and two products, trichodiene and diphosphate.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming). Other names in common use include trichodiene synthetase, sesquiterpene cyclase, and trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase. This enzyme participates in terpenoid biosynthesis.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1YJ4, 1YYQ, 1YYR, 1YYS, 1YYT, 1YYU, 2AEK, 2AEL, and 2AET.

[edit] References

• IUBMB entry for 4.2.3.6
• BRENDA references for 4.2.3.6 (Recommended.)
• PubMed references for 4.2.3.6
• PubMed Central references for 4.2.3.6
• Google Scholar references for 4.2.3.6
• Hohn TM, Vanmiddlesworth F (1986). "Purification and characterization of the sesquiterpene cyclase trichodiene synthetase from Fusarium sporotrichioides". Arch. Biochem. Biophys. 251: 756–61. PMID 3800398. 

[edit] External links

The CAS registry number for this enzyme class is 101915-76-8.

• IUBMB entry for 4.2.3.6

• KEGG entry for 4.2.3.6

• BRENDA entry for 4.2.3.6

• NiceZyme view of 4.2.3.6

• EC2PDB: PDB structures for 4.2.3.6

• PRIAM entry for 4.2.3.6

• PUMA2 entry for 4.2.3.6

• IntEnz: Integrated Enzyme entry for 4.2.3.6

• MetaCyc entry for 4.2.3.6

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0045482: trichodiene synthase

• AMIGO entry for GO code 0045482: trichodiene synthase