TRIM68

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Tripartite motif-containing 68
Identifiers
Symbol(s) TRIM68; FLJ10369; MGC126176; RNF137; SS-56
External IDs MGI: 2142077 HomoloGene: 9991
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 55128 101700
Ensembl ENSG00000167333 ENSMUSG00000073968
Uniprot Q6AZZ1 Q8K243
Refseq NM_018073 (mRNA)
NP_060543 (protein)		 XM_991271 (mRNA)
XP_996365 (protein)
Location Chr 11: 4.58 - 4.59 Mb Chr 7: 102.55 - 102.56 Mb
Pubmed search [1] [2]

Tripartite motif-containing 68, also known as TRIM68, is a human gene.[1]

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is expressed in many cancer cell lines. Its expression in normal tissues, however, was found to be restricted to prostate. This gene was also found to be differentially expressed in androgen-dependent versus androgen-independent prostate cancer cells.[1]

[edit] References

  1. ^ a b Entrez Gene: TRIM68 tripartite motif-containing 68.

[edit] Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863. 
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166. 
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287-92. doi:10.1093/embo-reports/kvd058. PMID 11256614. 
  • Billaut-Mulot O, Cocude C, Kolesnitchenko V, et al. (2001). "SS-56, a novel cellular target of autoantibody responses in Sjögren syndrome and systemic lupus erythematosus.". J. Clin. Invest. 108 (6): 861-9. PMID 11560955. 
  • Chang GT, Steenbeek M, Schippers E, et al. (2001). "A novel gene on human chromosome 2p24 is differentially expressed between androgen-dependent and androgen-independent prostate cancer cells.". Eur. J. Cancer 37 (16): 2129-34. PMID 11597395. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336. 
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901. 
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