TRIM29

From Wikipedia, the free encyclopedia

Tripartite motif-containing 29

PDB rendering based on 2csv.

Available structures: 2csv

Identifiers

Symbol(s)

TRIM29; ATDC; FLJ36085

External IDs

OMIM: 610658 HomoloGene: 8100

Gene ontology
Molecular Function:	• transcription factor activity • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• intracellular • cytoplasm
Biological Process:	• transcription from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

n/a

Refseq

NM_012101 (mRNA)
NP_036233 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 11: 119.49 - 119.51 Mb

n/a

Pubmed search

[1]

n/a

Tripartite motif-containing 29, also known as TRIM29, is a human gene.^[1]

The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype.^[1]

[edit] References

^ ^a ^b Entrez Gene: TRIM29 tripartite motif-containing 29.

[edit] Further reading

Kapp LN, Painter RB, Yu LC, et al. (1992). "Cloning of a candidate gene for ataxia-telangiectasia group D.". Am. J. Hum. Genet. 51 (1): 45–54. PMID 1609804.
Hosoi Y, Kapp LN (1995). "Expression of a candidate ataxia-telangiectasia group D gene in cultured fibroblast cell lines and human tissues.". Int. J. Radiat. Biol. 66 (6 Suppl): S71–6. PMID 7530755.
Brzoska PM, Chen H, Zhu Y, et al. (1995). "The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor.". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7824–8. PMID 7644499.
Murnane JP, Zhu Y, Young BR, Christman MF (1995). "Expression of the candidate A-T gene ATDC is not detectable in a human cell line with a normal response to ionizing radiation.". Int. J. Radiat. Biol. 66 (6 Suppl): S77–84. PMID 7836856.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Leonhardt EA, Kapp LN, Young BR, Murnane JP (1994). "Nucleotide sequence analysis of a candidate gene for ataxia-telangiectasia group D (ATDC).". Genomics 19 (1): 130–6. doi:10.1006/geno.1994.1022. PMID 8188213.
Richard CW, Cox DR, Kapp L, et al. (1993). "A radiation hybrid map of human chromosome 11q22-q23 containing the ataxia-telangiectasia disease locus.". Genomics 17 (1): 1–5. doi:10.1006/geno.1993.1275. PMID 8406440.
Laderoute KR, Knapp AM, Green CJ, et al. (1996). "Expression of the ATDC (ataxia telangiectasia group D-complementing) gene in A431 human squamous carcinoma cells.". Int. J. Cancer 66 (6): 772–8. doi:10.1002/(SICI)1097-0215(19960611)66:6<772::AID-IJC11>3.0.CO;2-5. PMID 8647648.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Tauchi H, Green C, Knapp M, et al. (2000). "Altered splicing of the ATDC message in ataxia telangiectasia group D cells results in the absence of a functional protein.". Mutagenesis 15 (2): 105–8. PMID 10719033.
Reymond A, Meroni G, Fantozzi A, et al. (2001). "The tripartite motif family identifies cell compartments.". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMID 11331580.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Hosoi Y, Kapp LN, Murnane JP, et al. (2006). "Suppression of anchorage-independent growth by expression of the ataxia-telangiectasia group D complementing gene, ATDC.". Biochem. Biophys. Res. Commun. 348 (2): 728–34. doi:10.1016/j.bbrc.2006.07.115. PMID 16890201.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.