TRIB2

From Wikipedia, the free encyclopedia

Tribbles homolog 2 (Drosophila)

Identifiers

TRIB2; GS3955; TRB2

External IDs

Gene ontology
Molecular Function:	• nucleotide binding • protein kinase activity • protein kinase inhibitor activity • ATP binding
Cellular Component:	• cytoplasm
Biological Process:	• protein amino acid phosphorylation • regulation of MAPK activity

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_021643 (mRNA)
NP_067675 (protein)

NM_144551 (mRNA)
NP_653134 (protein)

Location

Chr 2: 12.77 - 12.8 Mb

Chr 12: 15.82 - 15.84 Mb

Pubmed search

[1]

[2]

Tribbles homolog 2 (Drosophila), also known as TRIB2, is a human gene.^[1]

[edit] References

^ Entrez Gene: TRIB2 tribbles homolog 2 (Drosophila).

[edit] Further reading

Hegedus Z, Czibula A, Kiss-Toth E (2006). "Tribbles: novel regulators of cell function; evolutionary aspects.". Cell. Mol. Life Sci. 63 (14): 1632-41. doi:10.1007/s00018-006-6007-9. PMID 16715410.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Wu M, Xu LG, Zhai Z, Shu HB (2003). "SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription.". J. Biol. Chem. 278 (29): 27072-9. doi:10.1074/jbc.M209814200. PMID 12736262.
Kiss-Toth E, Bagstaff SM, Sung HY, et al. (2004). "Human tribbles, a protein family controlling mitogen-activated protein kinase cascades.". J. Biol. Chem. 279 (41): 42703-8. doi:10.1074/jbc.M407732200. PMID 15299019.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724-31. doi:10.1038/nature03466. PMID 15815621.
Zhang Y, Davis JL, Li W (2005). "Identification of tribbles homolog 2 as an autoantigen in autoimmune uveitis by phage display.". Mol. Immunol. 42 (11): 1275-81. doi:10.1016/j.molimm.2004.11.020. PMID 15950723.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801-14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Keeshan K, He Y, Wouters BJ, et al. (2007). "Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia.". Cancer Cell 10 (5): 401-11. doi:10.1016/j.ccr.2006.09.012. PMID 17097562.
Lin KR, Lee SF, Hung CM, et al. (2007). "Survival factor withdrawal-induced apoptosis of TF-1 cells involves a TRB2-Mcl-1 axis-dependent pathway.". J. Biol. Chem. 282 (30): 21962-72. doi:10.1074/jbc.M701663200. PMID 17545167.