Tre recombinase

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Tre recombinase is an experimental enzyme that in lab tests has successfully removed DNA inserted by HIV from infected cells^[1]. The enzyme was derived from Cre recombinase through selective mutation for the purposes of identifying HIV markers, which are not bounded by loxP sites and therefore disallow attempts at Cre-Lox recombination.

[edit] References

1. ^ Sarkar, I. et al. (2007): HIV-1 proviral DNA excision using an evolved recombinase. In: Science. Bd. 316, S. 1912-1915. PMID 17600219 doi:10.1126/science.1141453

[edit] External links

• Designer Enzyme Cuts HIV Out of Infected Cells
• Potential cure for HIV discovered^{[dead link]}
• HIV-1 Proviral DNA Excision Using an Evolved Recombinase