TREX2

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Three prime repair exonuclease 2
PDB rendering based on 1y97.
Available structures: 1y97
Identifiers
Symbol(s) TREX2;
External IDs OMIM: 300370 MGI: 1346343 HomoloGene: 8046
Orthologs
Human Mouse
Entrez 11219 24102
Ensembl n/a ENSMUSG00000031372
Uniprot n/a Q3SXB3
Refseq NM_080701 (mRNA)
NP_542432 (protein)		 NM_011907 (mRNA)
NP_036037 (protein)
Location n/a Chr X: 69.69 - 69.69 Mb
Pubmed search [1] [2]

Three prime repair exonuclease 2, also known as TREX2, is a human gene.[1]

This gene encodes a protein with 3' exonuclease activity. Enzymes with this activity are involved in DNA replication, repair, and recombination. Similarity to an E. coli protein suggests that this enzyme may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity.[1]

[edit] References

  1. ^ a b Entrez Gene: TREX2 three prime repair exonuclease 2.

[edit] Further reading

  • Shevelev IV, Hübscher U (2002). "The 3' 5' exonucleases.". Nat. Rev. Mol. Cell Biol. 3 (5): 364-76. doi:10.1038/nrm804. PMID 11988770. 
  • Esposito T, Ciccodicola A, Flagiello L, et al. (1997). "Expressed STSs and transcription of human Xq28.". Gene 187 (2): 185-91. PMID 9099879. 
  • Mazur DJ, Perrino FW (1999). "Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases.". J. Biol. Chem. 274 (28): 19655-60. PMID 10391904. 
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863. 
  • Li T, Duan W, Yang H, et al. (2001). "Identification of two proteins, S14 and UIP1, that interact with UCH37.". FEBS Lett. 488 (3): 201-5. PMID 11163772. 
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287-92. doi:10.1093/embo-reports/kvd058. PMID 11256614. 
  • Mazur DJ, Perrino FW (2001). "Structure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genes.". J. Biol. Chem. 276 (18): 14718-27. doi:10.1074/jbc.M010051200. PMID 11278605. 
  • Mazur DJ, Perrino FW (2001). "Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteins.". J. Biol. Chem. 276 (20): 17022-9. doi:10.1074/jbc.M100623200. PMID 11279105. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Shevelev IV, Beliakova NV, Kravetskaia TP, Krutiakov VM (2003). "[The correcting role of autonomous 3'-->5' exonucleases in mammalian multienzyme DNA polymerase complexes]". Mol. Biol. (Mosk.) 36 (6): 1055-61. PMID 12500544. 
  • Shevelev IV, Ramadan K, Hübscher U (2004). "The TREX2 3'-->5' exonuclease physically interacts with DNA polymerase delta and increases its accuracy.". ScientificWorldJournal 2: 275-81. doi:10.1100/tsw.2002.99. PMID 12806015. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336. 
  • Perrino FW, Krol A, Harvey S, et al. (2005). "Sequence variants in the 3'-->5' deoxyribonuclease TREX2: identification in a genetic screen and effects on catalysis by the recombinant proteins.". Adv. Enzyme Regul. 44: 37-49. doi:10.1016/j.advenzreg.2003.11.010. PMID 15581481. 
  • Perrino FW, Harvey S, McMillin S, Hollis T (2005). "The human TREX2 3' -> 5'-exonuclease structure suggests a mechanism for efficient nonprocessive DNA catalysis.". J. Biol. Chem. 280 (15): 15212-8. doi:10.1074/jbc.M500108200. PMID 15661738. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901. 
  • Hahn Y, Lee B (2007). "Human-specific nonsense mutations identified by genome sequence comparisons.". Hum. Genet. 119 (1-2): 169-78. doi:10.1007/s00439-005-0125-6. PMID 16395595. 
  • Chen MJ, Ma SM, Dumitrache LC, Hasty P (2007). "Biochemical and cellular characteristics of the 3' -> 5' exonuclease TREX2.". Nucleic Acids Res. 35 (8): 2682-94. doi:10.1093/nar/gkm151. PMID 17426129. 
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