TREML1

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Triggering receptor expressed on myeloid cells-like 1
PDB rendering based on 2frg.
Available structures: 2frg
Identifiers
Symbol(s) TREML1; GLTL1825; MGC119173; PRO3438; TLT-1; TLT1; dJ238O23.3
External IDs OMIM: 609714 MGI: 1918576 HomoloGene: 52257
Orthologs
Human Mouse
Entrez 340205 71326
Ensembl ENSG00000161911 ENSMUSG00000023993
Uniprot Q86YW5 Q8K558
Refseq NM_178174 (mRNA)
NP_835468 (protein)		 NM_027763 (mRNA)
NP_082039 (protein)
Location Chr 6: 41.22 - 41.23 Mb Chr 17: 47.83 - 47.83 Mb
Pubmed search [1] [2]

Triggering receptor expressed on myeloid cells-like 1, also known as TREML1, is a human gene.[1]

TREML1 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties. TREML1 enhances calcium signaling in an SHP2 (PTPN11; MIM 176876)-dependent manner (Allcock et al., 2003; Barrow et al., 2004).[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: TREML1 triggering receptor expressed on myeloid cells-like 1.

[edit] Further reading

  • Washington AV, Quigley L, McVicar DW (2003). "Initial characterization of TREM-like transcript (TLT)-1: a putative inhibitory receptor within the TREM cluster.". Blood 100 (10): 3822–4. doi:10.1182/blood-2002-02-0523. PMID 12393607. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Allcock RJ, Barrow AD, Forbes S, et al. (2003). "The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44.". Eur. J. Immunol. 33 (2): 567–77. doi:10.1002/immu.200310033. PMID 12645956. 
  • Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. 
  • Washington AV, Schubert RL, Quigley L, et al. (2005). "A TREM family member, TLT-1, is found exclusively in the alpha-granules of megakaryocytes and platelets.". Blood 104 (4): 1042–7. doi:10.1182/blood-2004-01-0315. PMID 15100151. 
  • Barrow AD, Astoul E, Floto A, et al. (2004). "Cutting edge: TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP-2.". J. Immunol. 172 (10): 5838–42. PMID 15128762. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Gattis JL, Washington AV, Chisholm MM, et al. (2006). "The structure of the extracellular domain of triggering receptor expressed on myeloid cells like transcript-1 and evidence for a naturally occurring soluble fragment.". J. Biol. Chem. 281 (19): 13396–403. doi:10.1074/jbc.M600489200. PMID 16505478. 
  • Giomarelli B, Washington VA, Chisholm MM, et al. (2007). "Inhibition of thrombin-induced platelet aggregation using human single-chain Fv antibodies specific for TREM-like transcript-1.". Thromb. Haemost. 97 (6): 955–63. PMID 17549298. 
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