Transformation/transcription domain-associated protein

From Wikipedia, the free encyclopedia

Identifiers

TRRAP; FLJ10671; PAF350/400; PAF400; STAF40; TR-AP; Tra1

External IDs

OMIM: 603015 MGI: 2153272 HomoloGene: 39246

Gene ontology
Molecular Function:	• transcription coactivator activity • protein binding • phosphotransferase activity, alcohol group as acceptor
Cellular Component:	• PCAF complex • nucleus • NuA4 histone acetyltransferase complex
Biological Process:	• regulation of transcription, DNA-dependent • mitotic cell cycle checkpoint • signal transduction • chromatin modification • histone acetylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003496 (mRNA)
NP_003487 (protein)

XM_891798 (mRNA)
XP_896891 (protein)

Location

Chr 7: 98.31 - 98.47 Mb

Chr 5: 145.02 - 145.11 Mb

Pubmed search

[1]

[2]

Transformation/transcription domain-associated protein, also known as TRRAP, is a human gene.

This is an adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Plays a central role in MYC (c-Myc) transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes.

[edit] Further reading

Herceg Z, Wang ZQ (2006). "Rendez-vous at mitosis: TRRAPed in the chromatin.". Cell Cycle 4 (3): 383-7. PMID 15711126.
Murr R, Vaissière T, Sawan C, et al. (2007). "Orchestration of chromatin-based processes: mind the TRRAP.". Oncogene 26 (37): 5358-72. doi:10.1038/sj.onc.1210605. PMID 17694078.
McMahon SB, Van Buskirk HA, Dugan KA, et al. (1998). "The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins.". Cell 94 (3): 363-74. PMID 9708738.
Vassilev A, Yamauchi J, Kotani T, et al. (1999). "The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily.". Mol. Cell 2 (6): 869-75. PMID 9885574.
Brand M, Yamamoto K, Staub A, Tora L (1999). "Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction.". J. Biol. Chem. 274 (26): 18285-9. PMID 10373431.
McMahon SB, Wood MA, Cole MD (2000). "The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc.". Mol. Cell. Biol. 20 (2): 556-62. PMID 10611234.
Ikura T, Ogryzko VV, Grigoriev M, et al. (2000). "Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis.". Cell 102 (4): 463-73. PMID 10966108.
Brand M, Moggs JG, Oulad-Abdelghani M, et al. (2001). "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation.". EMBO J. 20 (12): 3187-96. doi:10.1093/emboj/20.12.3187. PMID 11406595.
Lee YJ, Chung TS, Soo Yoon Y, et al. (2001). "The role of functional MR imaging in patients with ischemia in the visual cortex.". AJNR. American journal of neuroradiology 22 (6): 1043-9. PMID 11415895.
Lang SE, McMahon SB, Cole MD, Hearing P (2001). "E2F transcriptional activation requires TRRAP and GCN5 cofactors.". J. Biol. Chem. 276 (35): 32627-34. doi:10.1074/jbc.M102067200. PMID 11418595.
Park J, Kunjibettu S, McMahon SB, Cole MD (2001). "The ATM-related domain of TRRAP is required for histone acetyltransferase recruitment and Myc-dependent oncogenesis.". Genes Dev. 15 (13): 1619-24. doi:10.1101/gad.900101. PMID 11445536.
Fuchs M, Gerber J, Drapkin R, et al. (2001). "The p400 complex is an essential E1A transformation target.". Cell 106 (3): 297-307. PMID 11509179.
Martinez E, Palhan VB, Tjernberg A, et al. (2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.". Mol. Cell. Biol. 21 (20): 6782-95. doi:10.1128/MCB.21.20.6782-6795.2001. PMID 11564863.
Park J, Wood MA, Cole MD (2002). "BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation.". Mol. Cell. Biol. 22 (5): 1307-16. PMID 11839798.
Yanagisawa J, Kitagawa H, Yanagida M, et al. (2002). "Nuclear receptor function requires a TFTC-type histone acetyl transferase complex.". Mol. Cell 9 (3): 553-62. PMID 11931763.
Nikiforov MA, Chandriani S, Park J, et al. (2002). "TRRAP-dependent and TRRAP-independent transcriptional activation by Myc family oncoproteins.". Mol. Cell. Biol. 22 (14): 5054-63. PMID 12077335.
Ard PG, Chatterjee C, Kunjibettu S, et al. (2002). "Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes.". Mol. Cell. Biol. 22 (16): 5650-61. PMID 12138177.
Cavusoglu N, Brand M, Tora L, Van Dorsselaer A (2003). "Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis.". Proteomics 3 (2): 217-23. doi:10.1002/pmic.200390030. PMID 12601814.
Liu X, Tesfai J, Evrard YA, et al. (2003). "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation.". J. Biol. Chem. 278 (22): 20405-12. doi:10.1074/jbc.M211795200. PMID 12660246.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767-72. doi:10.1126/science.1083423. PMID 12690205.