Talk:Trazodone

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This page is a mess. Information is scattered everywhere and is not grouped together properly. For example, information about interactions is also under the precautions section. Sections 4, 5 and 6 also all belong in one large section with subdivisions. I'll clean it up eventually. Fuzzform 04:43, 11 May 2006 (UTC)

Note that trazodone is not a tetracyclic chemical (four joined rings), rather it has several separate cyclic structures. To quote 'Trazodone is a triazolopyridine derivative, chemically and structurally unrelated to tricyclic and tetracyclic antidepressants' Gribskov 11:54, 14 October 2006 (UTC)

Contents 1 Trazodone extended release 2 Permanent Erection 3 Side Effects 4 Fair use rationale for Image:DesyrelAd.png 5 mechanism of action - SRI?

[edit] Trazodone extended release

In Italy and in other European countries there is an extend release form of trazodone. Anyone know the different half-life, side effects profile etc compared to "normal" trazodone? I've made some searches but without luck...

Thanks

Artkin 11:24, 28 February 2007 (UTC)

I've taken the Trittico AC (extended release), so I know it. As with other ER-psychopharmaceuticals, the plasma concentration builds up more smoothly and peak concs are lower and occuring later than with immediate release galenics; the hypnagogic/sedative effects are thus less pronounced with the same dose Trittico AC than with Trittico. However, Trittico AC is to be taken only 1 or 2x daily, whereas Trittico should be taken 3x daily, if taken as antidepressant and/or anxiolytic. Side effects are also a bit less expressed with the extended-release form. As far as I know, the pharmacological properties of trazodone, i.e. half-life, metabolism and action is not different with the ext.-release, only some pharmacokinetics like c_MAX, t_MAX; AUC is almost the same with IR- and ER-galenic.--84.163.103.80 16:13, 3 April 2007 (UTC)

[edit] Permanent Erection

Apparently this is a rare side effect that requires some sort of operation to correct, but it doesn't seem to be mentioned in this article. --Mista-X 21:30, 9 July 2007 (UTC)

The condition is called Priapism. -- 24.226.115.176 00:43, 9 August 2007 (UTC)

Indeed, it's mentioned on the paient information here "Some men have reported long-lasting and painful erections with trazodone hydrochloride. If this happens to you, it is important that you stop taking trazodone hydrochloride and tell your doctor immediately." from the patient info from a Winthrop packet, ref MPE 67991 --SirXaph 04:53, 3 November 2007 (UTC)

[edit] Side Effects

uncontrollable laughter, sex drive increase. (Trazodone is also known to cause a "hangover effect" in patients prescribed the drug as a sleep aid: the "Trazodone hangover" generally ceases with regular use after three or four days.)

What is the source of these side effects? They don't seem to be mentioned in any other list of side effects that I could find. The "hangover effect" is not a common phase found in patient information or medical related publications. "Temporary grogginess" may be a possibly suitable phrase, but I wouldn't suggest adding it without verifying its suitability from authoritative source. 24.226.115.176 00:43, 9 August 2007 (UTC)

I would describe it as a suitable phrase and can imagine being referred to as such by patients, however it's not an encyclopedic term. The description I have here says - "drowsiness - this should wear off as you continue to take the tablets," then "headache, dizziness, confusion, feeling less alert.." and also "nausea and vomiting" and "weakness".. (from Winthrop patient information leaflet - MPE 67991) all similar to the symptoms of hangover, but really it's not really appropriate to refer to it in this way. Perhaps saying this way would be better:

Some of the more common side effects of taking Trazodone have been described by patients as feeling similar to a hangover, though these side effects often cease after regular use continues.

SirXaph 05:07, 3 November 2007 (UTC)

[edit] Fair use rationale for Image:DesyrelAd.png

Image:DesyrelAd.png is being used on this article. I notice the image page specifies that the image is being used under fair use but there is no explanation or rationale as to why its use in this Wikipedia article constitutes fair use. In addition to the boilerplate fair use template, you must also write out on the image description page a specific explanation or rationale for why using this image in each article is consistent with fair use.

Please go to the image description page and edit it to include a fair use rationale. Using one of the templates at Wikipedia:Fair use rationale guideline is an easy way to insure that your image is in compliance with Wikipedia policy, but remember that you must complete the template. Do not simply insert a blank template on an image page.

If there is other fair use media, consider checking that you have specified the fair use rationale on the other images used on this page. Note that any fair use images uploaded after 4 May, 2006, and lacking such an explanation will be deleted one week after they have been uploaded, as described on criteria for speedy deletion. If you have any questions please ask them at the Media copyright questions page. Thank you.

[edit] mechanism of action - SRI?

From my psychopharmacology notes I have nefazodone and trazodone listed as SARIs = serotonergic antagonists and reuptake inhibitors. Is there more than that single citation to support the argument that they do not possess SRI activity? ("Trazodone is not a serotonin reuptake inhibitor"). If there is not significant corroboration, I will change this part to reflect controversy rather than simply stating it's not an SRI.--Xris0 (talk) 14:58, 1 May 2008 (UTC)

BetacommandBot 08:55, 27 October 2007 (UTC)