TRAF1

From Wikipedia, the free encyclopedia

TNF receptor-associated factor 1

Identifiers

TRAF1; EBI6; MGC:10353

External IDs

OMIM: 601711 MGI: 101836 HomoloGene: 4138

Gene ontology
Molecular Function:	• serine-type endopeptidase inhibitor activity • protein binding • zinc ion binding
Cellular Component:	• cytoplasm
Biological Process:	• protein complex assembly • signal transduction • regulation of apoptosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005658 (mRNA)
NP_005649 (protein)

NM_009421 (mRNA)
NP_033447 (protein)

Location

Chr 9: 122.7 - 122.73 Mb

Chr 2: 34.77 - 34.78 Mb

Pubmed search

[1]

[2]

TNF receptor-associated factor 1, also known as TRAF1, is a human gene.

The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors.^[1]

[edit] References

^ Entrez Gene: TRAF1 TNF receptor-associated factor 1.

[edit] Further reading

Wajant H, Henkler F, Scheurich P (2001). "The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators.". Cell. Signal. 13 (6): 389–400. PMID 11384837.
Bradley JR, Pober JS (2001). "Tumor necrosis factor receptor-associated factors (TRAFs).". Oncogene 20 (44): 6482–91. doi:10.1038/sj.onc.1204788. PMID 11607847.
Hu HM, O'Rourke K, Boguski MS, Dixit VM (1994). "A novel RING finger protein interacts with the cytoplasmic domain of CD40.". J. Biol. Chem. 269 (48): 30069–72. PMID 7527023.
Mosialos G, Birkenbach M, Yalamanchili R, et al. (1995). "The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family.". Cell 80 (3): 389–99. PMID 7859281.
Rothe M, Wong SC, Henzel WJ, Goeddel DV (1994). "A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor.". Cell 78 (4): 681–92. PMID 8069916.
Hsu H, Shu HB, Pan MG, Goeddel DV (1996). "TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways.". Cell 84 (2): 299–308. PMID 8565075.
Hsu H, Huang J, Shu HB, et al. (1996). "TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex.". Immunity 4 (4): 387–96. PMID 8612133.
Lee SY, Park CG, Choi Y (1996). "T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors.". J. Exp. Med. 183 (2): 669–74. PMID 8627180.
Gedrich RW, Gilfillan MC, Duckett CS, et al. (1996). "CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins.". J. Biol. Chem. 271 (22): 12852–8. PMID 8662842.
Song HY, Rothe M, Goeddel DV (1996). "The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation.". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6721–5. PMID 8692885.
Takeuchi M, Rothe M, Goeddel DV (1996). "Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins.". J. Biol. Chem. 271 (33): 19935–42. PMID 8702708.
Rothe M, Xiong J, Shu HB, et al. (1996). "I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.". Proc. Natl. Acad. Sci. U.S.A. 93 (16): 8241–6. PMID 8710854.
Shu HB, Takeuchi M, Goeddel DV (1997). "The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex.". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 13973–8. PMID 8943045.
Ansieau S, Scheffrahn I, Mosialos G, et al. (1997). "Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation.". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 14053–8. PMID 8943059.
Lee SY, Lee SY, Choi Y (1997). "TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation.". J. Exp. Med. 185 (7): 1275–85. PMID 9104814.
Marsters SA, Ayres TM, Skubatch M, et al. (1997). "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1.". J. Biol. Chem. 272 (22): 14029–32. PMID 9162022.
Boucher LM, Marengère LE, Lu Y, et al. (1997). "Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily.". Biochem. Biophys. Res. Commun. 233 (3): 592–600. doi:10.1006/bbrc.1997.6509. PMID 9168896.
Shu HB, Halpin DR, Goeddel DV (1997). "Casper is an FADD- and caspase-related inducer of apoptosis.". Immunity 6 (6): 751–63. PMID 9208847.
Song HY, Régnier CH, Kirschning CJ, et al. (1997). "Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2.". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9792–6. PMID 9275204.
Siemienski K, Peters N, Scheurich P, Wajant H (1997). "Organization of the human tumour necrosis factor receptor-associated factor 1 (TRAF1) gene and mapping to chromosome 9q33-34.". Gene 195 (1): 35–9. PMID 9300817.