TRA@

From Wikipedia, the free encyclopedia

T cell receptor alpha locus

Identifiers

TRA@; FLJ22602; MGC117436; MGC22624; MGC23964; MGC71411; TCRA; TCRD; TRA; TRDD3

External IDs

Gene ontology
Molecular Function:	• receptor activity • protein binding • MHC protein binding • peptide antigen binding
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• cellular defense response

Orthologs

Human

Mouse

Entrez

6955

n/a

Pubmed search

[1]

n/a

T cell receptor alpha locus, also known as TRA@, is a human gene.^[1]

[edit] References

^ Entrez Gene: TRA@ T cell receptor alpha locus.

[edit] Further reading

Kenwrick S, Levinson B, Taylor S, et al. (1993). "Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene.". Hum. Mol. Genet. 1 (3): 179–86. PMID 1303175.
Suzuki CK, Bonifacino JS, Lin AY, et al. (1991). "Regulating the retention of T-cell receptor alpha chain variants within the endoplasmic reticulum: Ca(2+)-dependent association with BiP.". J. Cell Biol. 114 (2): 189–205. PMID 1649196.
Travis A, Amsterdam A, Belanger C, Grosschedl R (1991). "LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]". Genes Dev. 5 (5): 880–94. PMID 1827423.
Koning F, Maloy WL, Coligan JE (1990). "The implications of subunit interactions for the structure of the T cell receptor-CD3 complex.". Eur. J. Immunol. 20 (2): 299–305. PMID 2138083.
Dyer MJ (1989). "T-cell receptor delta/alpha rearrangements in lymphoid neoplasms.". Blood 74 (3): 1073–83. PMID 2546634.
Chilson OP, Kelly-Chilson AE (1989). "Mitogenic lectins bind to the antigen receptor on human lymphocytes.". Eur. J. Immunol. 19 (2): 389–96. PMID 2703017.
Yanagi Y, Chan A, Chin B, et al. (1985). "Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line.". Proc. Natl. Acad. Sci. U.S.A. 82 (10): 3430–4. PMID 3873654.
Erikson J, Williams DL, Finan J, et al. (1985). "Locus of the alpha-chain of the T-cell receptor is split by chromosome translocation in T-cell leukemias.". Science 229 (4715): 784–6. PMID 3875152.
Rabbitts TH, Lefranc MP, Stinson MA, et al. (1985). "The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia.". EMBO J. 4 (6): 1461–5. PMID 3875483.
Sim GK, Yagüe J, Nelson J, et al. (1985). "Primary structure of human T-cell receptor alpha-chain.". Nature 312 (5996): 771–5. PMID 6440030.
Kearse KP, Roberts JL, Singer A (1995). "TCR alpha-CD3 delta epsilon association is the initial step in alpha beta dimer formation in murine T cells and is limiting in immature CD4+ CD8+ thymocytes.". Immunity 2 (4): 391–9. PMID 7719941.
Manolios N, Kemp O, Li ZG (1994). "The T cell antigen receptor alpha and beta chains interact via distinct regions with CD3 chains.". Eur. J. Immunol. 24 (1): 84–92. PMID 8020575.
Bagga R, Emerson BM (1997). "An HMG I/Y-containing repressor complex and supercoiled DNA topology are critical for long-range enhancer-dependent transcription in vitro.". Genes Dev. 11 (5): 629–39. PMID 9119227.
San José E, Sahuquillo AG, Bragado R, Alarcón B (1998). "Assembly of the TCR/CD3 complex: CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a double TCR heterodimer model.". Eur. J. Immunol. 28 (1): 12–21. PMID 9485181.
Ding YH, Smith KJ, Garboczi DN, et al. (1998). "Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids.". Immunity 8 (4): 403–11. PMID 9586631.
Kirchgessner H, Dietrich J, Scherer J, et al. (2001). "The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain.". J. Exp. Med. 193 (11): 1269–84. PMID 11390434.
Shelton JG, Gülland S, Nicolson K, et al. (2001). "Importance of the T cell receptor alpha-chain transmembrane distal region for assembly with cognate subunits.". Mol. Immunol. 38 (4): 259–65. PMID 11566319.
Pietra G, Romagnani C, Falco M, et al. (2002). "The analysis of the natural killer-like activity of human cytolytic T lymphocytes revealed HLA-E as a novel target for TCR alpha/beta-mediated recognition.". Eur. J. Immunol. 31 (12): 3687–93. PMID 11745389.
Hennecke J, Wiley DC (2002). "Structure of a complex of the human alpha/beta T cell receptor (TCR) HA1.7, influenza hemagglutinin peptide, and major histocompatibility complex class II molecule, HLA-DR4 (DRA*0101 and DRB1*0401): insight into TCR cross-restriction and alloreactivity.". J. Exp. Med. 195 (5): 571–81. PMID 11877480.
García P, Llano M, de Heredia AB, et al. (2002). "Human T cell receptor-mediated recognition of HLA-E.". Eur. J. Immunol. 32 (4): 936–44. PMID 11920559.