TPD52

From Wikipedia, the free encyclopedia

Tumor protein D52

Identifiers

TPD52; PC-1; D52; N8L; PrLZ; hD52

External IDs

OMIM: 604068 MGI: 107749 HomoloGene: 38007

Gene ontology
Molecular Function:	• calcium ion binding • protein homodimerization activity • protein heterodimerization activity
Cellular Component:	• cytoplasm • endoplasmic reticulum • perinuclear region of cytoplasm
Biological Process:	• anatomical structure morphogenesis • B cell differentiation • secretion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001025252 (mRNA)
NP_001020423 (protein)

NM_001025261 (mRNA)
NP_001020432 (protein)

Location

Chr 8: 81.11 - 81.25 Mb

Chr 3: 8.91 - 8.95 Mb

Pubmed search

[1]

[2]

Tumor protein D52, also known as TPD52, is a human gene.^[1]

[edit] References

^ Entrez Gene: TPD52 tumor protein D52.

[edit] Further reading

Byrne JA, Tomasetto C, Garnier JM, et al. (1995). "A screening method to identify genes commonly overexpressed in carcinomas and the identification of a novel complementary DNA sequence.". Cancer Res. 55 (13): 2896–903. PMID 7796418.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Chen SL, Maroulakou IG, Green JE, et al. (1996). "Isolation and characterization of a novel gene expressed in multiple cancers.". Oncogene 12 (4): 741–51. PMID 8632896.
Byrne JA, Mattei MG, Basset P (1996). "Definition of the tumor protein D52 (TPD52) gene family through cloning of D52 homologues in human (hD53) and mouse (mD52).". Genomics 35 (3): 523–32. doi:10.1006/geno.1996.0393. PMID 8812487.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Byrne JA, Nourse CR, Basset P, Gunning P (1998). "Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system.". Oncogene 16 (7): 873–81. doi:10.1038/sj.onc.1201604. PMID 9484778.
Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins.". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.
Wilson SH, Bailey AM, Nourse CR, et al. (2001). "Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system.". Genomics 76 (1-3): 81–8. doi:10.1006/geno.2001.6610. PMID 11549320.
Sathasivam P, Bailey AM, Crossley M, Byrne JA (2001). "The role of the coiled-coil motif in interactions mediated by TPD52.". Biochem. Biophys. Res. Commun. 288 (1): 56–61. doi:10.1006/bbrc.2001.5721. PMID 11594751.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Boutros R, Bailey AM, Wilson SH, Byrne JA (2003). "Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins.". J. Mol. Biol. 332 (3): 675–87. PMID 12963375.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Wang R, Xu J, Saramäki O, et al. (2004). "PrLZ, a novel prostate-specific and androgen-responsive gene of the TPD52 family, amplified in chromosome 8q21.1 and overexpressed in human prostate cancer.". Cancer Res. 64 (5): 1589–94. PMID 14996714.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Tiacci E, Orvietani PL, Bigerna B, et al. (2005). "Tumor protein D52 (TPD52): a novel B-cell/plasma-cell molecule with unique expression pattern and Ca(2+)-dependent association with annexin VI.". Blood 105 (7): 2812–20. doi:10.1182/blood-2004-07-2630. PMID 15576473.
Byrne JA, Balleine RL, Schoenberg Fejzo M, et al. (2005). "Tumor protein D52 (TPD52) is overexpressed and a gene amplification target in ovarian cancer.". Int. J. Cancer 117 (6): 1049–54. doi:10.1002/ijc.21250. PMID 15986428.
Boutros R, Byrne JA (2005). "D53 (TPD52L1) is a cell cycle-regulated protein maximally expressed at the G2-M transition in breast cancer cells.". Exp. Cell Res. 310 (1): 152–65. doi:10.1016/j.yexcr.2005.07.009. PMID 16112108.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Barbaric D, Byth K, Dalla-Pozza L, Byrne JA (2007). "Expression of tumor protein D52-like genes in childhood leukemia at diagnosis: clinical and sample considerations.". Leuk. Res. 30 (11): 1355–63. doi:10.1016/j.leukres.2006.03.009. PMID 16620967.
Cao Q, Chen J, Zhu L, et al. (2006). "A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins.". Biochem. Biophys. Res. Commun. 344 (3): 798–806. doi:10.1016/j.bbrc.2006.03.208. PMID 16631610.