TPD52L1

From Wikipedia, the free encyclopedia

Tumor protein D52-like 1

Identifiers

TPD52L1; D53; MGC8556; TPD52L2; hD53

External IDs

OMIM: 604069 MGI: 1298386 HomoloGene: 2468

Gene ontology
Molecular Function:	• protein binding • caspase activator activity • protein homodimerization activity • protein heterodimerization activity
Cellular Component:	• cytoplasm • perinuclear region of cytoplasm
Biological Process:	• G2/M transition of mitotic cell cycle • DNA fragmentation during apoptosis • induction of apoptosis • positive regulation of MAPK activity • positive regulation of JNK cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001003395 (mRNA)
NP_001003395 (protein)

NM_009413 (mRNA)
NP_033439 (protein)

Location

Chr 6: 125.52 - 125.63 Mb

Chr 10: 31.02 - 31.07 Mb

Pubmed search

[1]

[2]

Tumor protein D52-like 1, also known as TPD52L1, is a human gene.^[1]

This gene encodes a member of the tumor protein D52 (TPD52) family. The encoded protein contains a coiled-coil domain and may form homo- or hetero-dimer with TPD52 family members. The protein is reported to be involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed, but the full-length nature of some variants has not yet been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: TPD52L1 tumor protein D52-like 1.

[edit] Further reading

Byrne JA, Tomasetto C, Garnier JM, et al. (1995). "A screening method to identify genes commonly overexpressed in carcinomas and the identification of a novel complementary DNA sequence.". Cancer Res. 55 (13): 2896–903. PMID 7796418.
Byrne JA, Mattei MG, Basset P (1996). "Definition of the tumor protein D52 (TPD52) gene family through cloning of D52 homologues in human (hD53) and mouse (mD52).". Genomics 35 (3): 523–32. doi:10.1006/geno.1996.0393. PMID 8812487.
Byrne JA, Nourse CR, Basset P, Gunning P (1998). "Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system.". Oncogene 16 (7): 873–81. doi:10.1038/sj.onc.1201604. PMID 9484778.
Byrne JA, Mattei MG, Basset P, Gunning P (1998). "Identification and in situ hybridization mapping of a mouse Tpd52l1 (D53) orthologue to chromosome 10A4-B2.". Cytogenet. Cell Genet. 81 (3-4): 199–201. PMID 9730602.
Wilson SH, Bailey AM, Nourse CR, et al. (2001). "Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system.". Genomics 76 (1-3): 81–8. doi:10.1006/geno.2001.6610. PMID 11549320.
Sathasivam P, Bailey AM, Crossley M, Byrne JA (2001). "The role of the coiled-coil motif in interactions mediated by TPD52.". Biochem. Biophys. Res. Commun. 288 (1): 56–61. doi:10.1006/bbrc.2001.5721. PMID 11594751.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Boutros R, Bailey AM, Wilson SH, Byrne JA (2003). "Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins.". J. Mol. Biol. 332 (3): 675–87. PMID 12963375.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Cho S, Ko HM, Kim JM, et al. (2004). "Positive regulation of apoptosis signal-regulating kinase 1 by hD53L1.". J. Biol. Chem. 279 (16): 16050–6. doi:10.1074/jbc.M305758200. PMID 14761963.
Boutros R, Byrne JA (2005). "D53 (TPD52L1) is a cell cycle-regulated protein maximally expressed at the G2-M transition in breast cancer cells.". Exp. Cell Res. 310 (1): 152–65. doi:10.1016/j.yexcr.2005.07.009. PMID 16112108.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Barbaric D, Byth K, Dalla-Pozza L, Byrne JA (2007). "Expression of tumor protein D52-like genes in childhood leukemia at diagnosis: clinical and sample considerations.". Leuk. Res. 30 (11): 1355–63. doi:10.1016/j.leukres.2006.03.009. PMID 16620967.
Cao Q, Chen J, Zhu L, et al. (2006). "A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins.". Biochem. Biophys. Res. Commun. 344 (3): 798–806. doi:10.1016/j.bbrc.2006.03.208. PMID 16631610.