TP53BP1

From Wikipedia, the free encyclopedia

Tumor protein p53 binding protein, 1

PDB rendering based on 1gzh.

Available structures: 1gzh, 1kzy, 1ssf, 1xni, 2g3r, 2ig0

Identifiers

Symbol(s)

TP53BP1; 53BP1; FLJ41424; MGC138366; p202

External IDs

OMIM: 605230 MGI: 1351320 HomoloGene: 4137

Gene ontology
Molecular Function:	• damaged DNA binding • protein binding • transcription activator activity
Cellular Component:	• kinetochore • intracellular • nucleus • nucleoplasm • replication fork • cytoplasm
Biological Process:	• DNA repair • transcription • positive regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005657 (mRNA)
NP_005648 (protein)

NM_013735 (mRNA)
NP_038763 (protein)

Location

Chr 15: 41.49 - 41.59 Mb

Chr 2: 120.88 - 120.96 Mb

Pubmed search

[1]

[2]

Tumor protein p53 binding protein, 1, also known as TP53BP1, is a human gene.^[1]

[edit] References

^ Entrez Gene: TP53BP1 tumor protein p53 binding protein 1.

[edit] Further reading

Choubey D, Lengyel P (1995). "Binding of an interferon-inducible protein (p202) to the retinoblastoma protein.". J. Biol. Chem. 270 (11): 6134–40. PMID 7890747.
Iwabuchi K, Bartel PL, Li B, et al. (1994). "Two cellular proteins that bind to wild-type but not mutant p53.". Proc. Natl. Acad. Sci. U.S.A. 91 (13): 6098–102. PMID 8016121.
Choubey D, Li SJ, Datta B, et al. (1996). "Inhibition of E2F-mediated transcription by p202.". EMBO J. 15 (20): 5668–78. PMID 8896460.
Datta B, Li B, Choubey D, et al. (1996). "p202, an interferon-inducible modulator of transcription, inhibits transcriptional activation by the p53 tumor suppressor protein, and a segment from the p53-binding protein 1 that binds to p202 overcomes this inhibition.". J. Biol. Chem. 271 (44): 27544–55. PMID 8910340.
Iwabuchi K, Li B, Massa HF, et al. (1998). "Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2.". J. Biol. Chem. 273 (40): 26061–8. PMID 9748285.
Wen Y, Yan DH, Spohn B, et al. (2000). "Tumor suppression and sensitization to tumor necrosis factor alpha-induced apoptosis by an interferon-inducible protein, p202, in breast cancer cells.". Cancer Res. 60 (1): 42–6. PMID 10646849.
Xia Z, Morales JC, Dunphy WG, Carpenter PB (2001). "Negative cell cycle regulation and DNA damage-inducible phosphorylation of the BRCT protein 53BP1.". J. Biol. Chem. 276 (4): 2708–18. doi:10.1074/jbc.M007665200. PMID 11042216.
Joo WS, Jeffrey PD, Cantor SB, et al. (2002). "Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure.". Genes Dev. 16 (5): 583–93. doi:10.1101/gad.959202. PMID 11877378.
Derbyshire DJ, Basu BP, Serpell LC, et al. (2002). "Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor.". EMBO J. 21 (14): 3863–72. doi:10.1093/emboj/cdf383. PMID 12110597.
Lai H, Lin L, Nadji M, et al. (2002). "Mutations in the p53 tumor suppressor gene and early onset breast cancer.". Cancer Biol. Ther. 1 (1): 31–6. PMID 12170762.
Derbyshire DJ, Basu BP, Date T, et al. (2003). "Purification, crystallization and preliminary X-ray analysis of the BRCT domains of human 53BP1 bound to the p53 tumour suppressor.". Acta Crystallogr. D Biol. Crystallogr. 58 (Pt 10 Pt 2): 1826–9. PMID 12351827.
Wang B, Matsuoka S, Carpenter PB, Elledge SJ (2002). "53BP1, a mediator of the DNA damage checkpoint.". Science 298 (5597): 1435–8. doi:10.1126/science.1076182. PMID 12364621.
Richie CT, Peterson C, Lu T, et al. (2003). "hSnm1 colocalizes and physically associates with 53BP1 before and after DNA damage.". Mol. Cell. Biol. 22 (24): 8635–47. PMID 12446782.
DiTullio RA, Mochan TA, Venere M, et al. (2003). "53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer.". Nat. Cell Biol. 4 (12): 998–1002. doi:10.1038/ncb892. PMID 12447382.
Fernandez-Capetillo O, Chen HT, Celeste A, et al. (2003). "DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1.". Nat. Cell Biol. 4 (12): 993–7. doi:10.1038/ncb884. PMID 12447390.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Peng A, Chen PL (2003). "NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage.". J. Biol. Chem. 278 (11): 8873–6. doi:10.1074/jbc.C300001200. PMID 12551934.
Stewart GS, Wang B, Bignell CR, et al. (2003). "MDC1 is a mediator of the mammalian DNA damage checkpoint.". Nature 421 (6926): 961–6. doi:10.1038/nature01446. PMID 12607005.
Yan DH, Abramian A, Li Z, et al. (2003). "P202, an interferon-inducible protein, inhibits E2F1-mediated apoptosis in prostate cancer cells.". Biochem. Biophys. Res. Commun. 303 (1): 219–22. PMID 12646190.
Kao GD, McKenna WG, Guenther MG, et al. (2003). "Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response.". J. Cell Biol. 160 (7): 1017–27. doi:10.1083/jcb.200209065. PMID 12668657.