TOP3A

From Wikipedia, the free encyclopedia

Topoisomerase (DNA) III alpha

Identifiers

External IDs

OMIM: 601243 MGI: 1197527 HomoloGene: 3394

Gene ontology
Molecular Function:	• DNA topoisomerase type I activity • zinc ion binding • metal ion binding
Cellular Component:	• nucleus • chromosome
Biological Process:	• DNA topological change • DNA unwinding during replication • DNA modification • chromosome organization and biogenesis (sensu Eukaryota) • meiosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004618 (mRNA)
NP_004609 (protein)

XM_001000921 (mRNA)
XP_001000921 (protein)

Location

Chr 17: 18.12 - 18.16 Mb

Chr 11: 60.56 - 60.59 Mb

Pubmed search

[1]

[2]

Topoisomerase (DNA) III alpha, also known as TOP3A, is a human gene.^[1]

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells.^[1]

[edit] References

^ ^a ^b Entrez Gene: TOP3A topoisomerase (DNA) III alpha.

[edit] Further reading

Hanai R, Caron PR, Wang JC (1996). "Human TOP3: a single-copy gene encoding DNA topoisomerase III.". Proc. Natl. Acad. Sci. U.S.A. 93 (8): 3653–7. PMID 8622991.
Fritz E, Elsea SH, Patel PI, Meyn MS (1997). "Overexpression of a truncated human topoisomerase III partially corrects multiple aspects of the ataxia-telangiectasia phenotype.". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4538–42. PMID 9114025.
Elsea SH, Fritz E, Schoener-Scott R, et al. (1998). "Gene for topoisomerase III maps within the Smith-Magenis syndrome critical region: analysis of cell-cycle distribution and radiation sensitivity.". Am. J. Med. Genet. 75 (1): 104–8. PMID 9450867.
Kim JC, Yoon JB, Koo HS, Chung IK (1998). "Cloning and characterization of the 5'-flanking region for the human topoisomerase III gene.". J. Biol. Chem. 273 (40): 26130–7. PMID 9748294.
Goulaouic H, Roulon T, Flamand O, et al. (1999). "Purification and characterization of human DNA topoisomerase IIIalpha.". Nucleic Acids Res. 27 (12): 2443–50. PMID 10352172.
Shimamoto A, Nishikawa K, Kitao S, Furuichi Y (2000). "Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta.". Nucleic Acids Res. 28 (7): 1647–55. PMID 10710432.
Wu L, Davies SL, North PS, et al. (2000). "The Bloom's syndrome gene product interacts with topoisomerase III.". J. Biol. Chem. 275 (13): 9636–44. PMID 10734115.
Lin CW, Darzynkiewicz Z, Li X, et al. (2000). "Differential expression of human topoisomerase IIIalpha during the cell cycle progression in HL-60 leukemia cells and human peripheral blood lymphocytes.". Exp. Cell Res. 256 (1): 225–36. doi:10.1006/excr.1999.4778. PMID 10739669.
Brosh RM, Li JL, Kenny MK, et al. (2000). "Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity.". J. Biol. Chem. 275 (31): 23500–8. doi:10.1074/jbc.M001557200. PMID 10825162.
Lodge AJ, Anderson JJ, Ng SW, et al. (2000). "Expression of topoisomerase IIIalpha in normal and neoplastic tissues determined by immunohistochemistry using a novel monoclonal antibody.". Br. J. Cancer 83 (4): 498–505. doi:10.1054/bjoc.2000.1293. PMID 10945498.
Hu P, Beresten SF, van Brabant AJ, et al. (2001). "Evidence for BLM and Topoisomerase IIIalpha interaction in genomic stability.". Hum. Mol. Genet. 10 (12): 1287–98. PMID 11406610.
Freire R, d'Adda Di Fagagna F, Wu L, et al. (2001). "Cleavage of the Bloom's syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with topoisomerase IIIalpha.". Nucleic Acids Res. 29 (15): 3172–80. PMID 11470874.
Bi W, Yan J, Stankiewicz P, et al. (2002). "Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse.". Genome Res. 12 (5): 713–28. doi:10.1101/gr.73702. PMID 11997338.
Wang Y, Lyu YL, Wang JC (2002). "Dual localization of human DNA topoisomerase IIIalpha to mitochondria and nucleus.". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12114–9. doi:10.1073/pnas.192449499. PMID 12209014.
Wu L, Hickson ID (2002). "The Bloom's syndrome helicase stimulates the activity of human topoisomerase IIIalpha.". Nucleic Acids Res. 30 (22): 4823–9. PMID 12433984.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Meetei AR, de Winter JP, Medhurst AL, et al. (2003). "A novel ubiquitin ligase is deficient in Fanconi anemia.". Nat. Genet. 35 (2): 165–70. doi:10.1038/ng1241. PMID 12973351.
Jiao R, Bachrati CZ, Pedrazzi G, et al. (2004). "Physical and functional interaction between the Bloom's syndrome gene product and the largest subunit of chromatin assembly factor 1.". Mol. Cell. Biol. 24 (11): 4710–9. doi:10.1128/MCB.24.11.4710-4719.2004. PMID 15143166.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Yin J, Sobeck A, Xu C, et al. (2005). "BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity.". EMBO J. 24 (7): 1465–76. doi:10.1038/sj.emboj.7600622. PMID 15775963.