TOMM22

From Wikipedia, the free encyclopedia

Translocase of outer mitochondrial membrane 22 homolog (yeast)

Identifiers

TOMM22; 1C9-2; MST065; MSTP065; TOM22

External IDs

OMIM: 607046 MGI: 2450248 HomoloGene: 10638

Gene ontology
Molecular Function:	• receptor activity
Cellular Component:	• mitochondrion • mitochondrial outer membrane translocase complex • membrane • integral to membrane • outer membrane
Biological Process:	• protein targeting to mitochondrion • protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_020243 (mRNA)
NP_064628 (protein)

NM_172609 (mRNA)
NP_766197 (protein)

Location

Chr 22: 37.41 - 37.41 Mb

n/a

Pubmed search

[1]

[2]

Translocase of outer mitochondrial membrane 22 homolog (yeast), also known as TOMM22, is a human gene.^[1]

The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded protein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolic preproteins into the mitochondrion.^[1]

[edit] References

^ ^a ^b Entrez Gene: TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast).

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Saeki K, Suzuki H, Tsuneoka M, et al. (2000). "Identification of mammalian TOM22 as a subunit of the preprotein translocase of the mitochondrial outer membrane.". J. Biol. Chem. 275 (41): 31996–2002. doi:10.1074/jbc.M004794200. PMID 10900208.
Suzuki H, Okazawa Y, Komiya T, et al. (2001). "Characterization of rat TOM40, a central component of the preprotein translocase of the mitochondrial outer membrane.". J. Biol. Chem. 275 (48): 37930–6. doi:10.1074/jbc.M006558200. PMID 10980201.
Yano M, Hoogenraad N, Terada K, Mori M (2000). "Identification and functional analysis of human Tom22 for protein import into mitochondria.". Mol. Cell. Biol. 20 (19): 7205–13. PMID 10982837.
Johnston AJ, Hoogenraad J, Dougan DA, et al. (2003). "Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane.". J. Biol. Chem. 277 (44): 42197–204. doi:10.1074/jbc.M205613200. PMID 12198123.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Yano M, Terada K, Mori M (2003). "AIP is a mitochondrial import mediator that binds to both import receptor Tom20 and preproteins.". J. Cell Biol. 163 (1): 45–56. doi:10.1083/jcb.200305051. PMID 14557246.
Yano M, Terada K, Mori M (2004). "Mitochondrial import receptors Tom20 and Tom22 have chaperone-like activity.". J. Biol. Chem. 279 (11): 10808–13. doi:10.1074/jbc.M311710200. PMID 14699115.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Humphries AD, Streimann IC, Stojanovski D, et al. (2005). "Dissection of the mitochondrial import and assembly pathway for human Tom40.". J. Biol. Chem. 280 (12): 11535–43. doi:10.1074/jbc.M413816200. PMID 15644312.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Bellot G, Cartron PF, Er E, et al. (2007). "TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax.". Cell Death Differ. 14 (4): 785–94. doi:10.1038/sj.cdd.4402055. PMID 17096026.