TNNI2

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Troponin I type 2 (skeletal, fast)
PDB rendering based on 1a2x.
Available structures: 1a2x, 1vdi, 1vdj
Identifiers
Symbol(s) TNNI2; AMCD2B; DA2B; FSSV
External IDs OMIM: 191043 MGI: 105070 HomoloGene: 37752
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 7136 21953
Ensembl ENSG00000130598 ENSMUSG00000031097
Uniprot P48788 P13412
Refseq NM_003282 (mRNA)
NP_003273 (protein)		 NM_009405 (mRNA)
NP_033431 (protein)
Location Chr 11: 1.82 - 1.82 Mb Chr 7: 142.25 - 142.25 Mb
Pubmed search [1] [2]

Troponin I type 2 (skeletal, fast), also known as TNNI2, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: TNNI2 troponin I type 2 (skeletal, fast).

[edit] Further reading

  • Kinoshita S, Adachi W, Sotozono C, et al. (2001). "Characteristics of the human ocular surface epithelium.". Progress in retinal and eye research 20 (5): 639-73. PMID 11470454. 
  • Wade R, Eddy R, Shows TB, Kedes L (1990). "cDNA sequence, tissue-specific expression, and chromosomal mapping of the human slow-twitch skeletal muscle isoform of troponin I.". Genomics 7 (3): 346-57. PMID 2365354. 
  • Huang TS, Bylund DB, Stull JT, Krebs EG (1974). "The amino acid sequences of the phosphorylated sites in troponin-I from rabbit skeletal muscle.". FEBS Lett. 42 (3): 249-52. PMID 4369265. 
  • Moir AJ, Ordidge M, Grand RJ, et al. (1983). "Studies of the interaction of troponin I with proteins of the I-filament and calmodulin.". Biochem. J. 209 (2): 417-26. PMID 6847627. 
  • Grand RJ, Levine BA, Perry SV (1982). "Proton-magnetic-resonance studies on the interaction of rabbit skeletal-muscle troponin I with troponin C and actin.". Biochem. J. 203 (1): 61-8. PMID 7103951. 
  • Chong PC, Hodges RS (1982). "Photochemical cross-linking between rabbit skeletal troponin subunits. Troponin I-troponin T interactions.". J. Biol. Chem. 257 (19): 11667-72. PMID 7118902. 
  • Zhu L, Perez-Alvarado G, Wade R (1994). "Sequencing of a cDNA encoding the human fast-twitch skeletal muscle isoform of troponin I.". Biochim. Biophys. Acta 1217 (3): 338-40. PMID 8148383. 
  • Lanfranchi G, Muraro T, Caldara F, et al. (1996). "Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing and filter hybridization.". Genome Res. 6 (1): 35-42. PMID 8681137. 
  • Jha PK, Leavis PC, Sarkar S (1997). "Interaction of deletion mutants of troponins I and T: COOH-terminal truncation of troponin T abolishes troponin I binding and reduces Ca2+ sensitivity of the reconstituted regulatory system.". Biochemistry 35 (51): 16573-80. doi:10.1021/bi9622433. PMID 8987992. 
  • Tiso N, Rampoldi L, Pallavicini A, et al. (1997). "Fine mapping of five human skeletal muscle genes: alpha-tropomyosin, beta-tropomyosin, troponin-I slow-twitch, troponin-I fast-twitch, and troponin-C fast.". Biochem. Biophys. Res. Commun. 230 (2): 347-50. doi:10.1006/bbrc.1996.5958. PMID 9016781. 
  • Stefancsik R, Jha PK, Sarkar S (1998). "Identification and mutagenesis of a highly conserved domain in troponin T responsible for troponin I binding: potential role for coiled coil interaction.". Proc. Natl. Acad. Sci. U.S.A. 95 (3): 957-62. PMID 9448267. 
  • Vassylyev DG, Takeda S, Wakatsuki S, et al. (1998). "Crystal structure of troponin C in complex with troponin I fragment at 2.3-A resolution.". Proc. Natl. Acad. Sci. U.S.A. 95 (9): 4847-52. PMID 9560191. 
  • Jha PK, Sarkar S (1998). "A recombinant monocysteine mutant (Ser to Cys-155) of fast skeletal troponin T: identification by cross-linking of a domain involved in a physiologically relevant interaction with troponins C and I.". Biochemistry 37 (35): 12253-60. doi:10.1021/bi980025z. PMID 9724539. 
  • Moses MA, Wiederschain D, Wu I, et al. (1999). "Troponin I is present in human cartilage and inhibits angiogenesis.". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2645-50. PMID 10077564. 
  • Mullen AJ, Barton PJ (2000). "Structural characterization of the human fast skeletal muscle troponin I gene (TNNI2).". Gene 242 (1-2): 313-20. PMID 10721725. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Sung SS, Brassington AM, Grannatt K, et al. (2003). "Mutations in genes encoding fast-twitch contractile proteins cause distal arthrogryposis syndromes.". Am. J. Hum. Genet. 72 (3): 681-90. PMID 12592607. 
  • Li Q, Liu Y, Shen PY, et al. (2003). "Troponin I binds polycystin-L and inhibits its calcium-induced channel activation.". Biochemistry 42 (24): 7618-25. doi:10.1021/bi034210a. PMID 12809519. 
  • Thijssen VL, Ausma J, Gorza L, et al. (2005). "Troponin I isoform expression in human and experimental atrial fibrillation.". Circulation 110 (7): 770-5. doi:10.1161/01.CIR.0000138849.03311.C6. PMID 15289369. 
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