TNKS

From Wikipedia, the free encyclopedia

Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase

Identifiers

TNKS; PARPL; PARP-5a; PARP5A; TIN1; TINF1; TNKS1

External IDs

OMIM: 603303 MGI: 1341087 HomoloGene: 18405

Gene ontology
Molecular Function:	• NAD+ ADP-ribosyltransferase activity • protein binding • transferase activity, transferring glycosyl groups
Cellular Component:	• chromosome, telomeric region • nucleus • chromosome
Biological Process:	• protein amino acid ADP-ribosylation • telomere maintenance via telomerase

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_003747 (mRNA)
NP_003738 (protein)

NM_175091 (mRNA)
NP_780300 (protein)

Location

Chr 8: 9.45 - 9.68 Mb

Chr 8: 36.3 - 36.43 Mb

Pubmed search

[1]

[2]

Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase, also known as TNKS, is a human gene.^[1]

[edit] References

^ Entrez Gene: TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase.

[edit] Further reading

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353-8. PMID 9110174.
Smith S, Giriat I, Schmitt A, de Lange T (1998). "Tankyrase, a poly(ADP-ribose) polymerase at human telomeres.". Science 282 (5393): 1484-7. PMID 9822378.
Zhu L, Smith S, de Lange T, Seldin MF (1999). "Chromosomal mapping of the tankyrase gene in human and mouse.". Genomics 57 (2): 320-1. doi:10.1006/geno.1999.5771. PMID 10198177.
Smith S, de Lange T (1999). "Cell cycle dependent localization of the telomeric PARP, tankyrase, to nuclear pore complexes and centrosomes.". J. Cell. Sci. 112 ( Pt 21): 3649-56. PMID 10523501.
Chi NW, Lodish HF (2001). "Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles.". J. Biol. Chem. 275 (49): 38437-44. doi:10.1074/jbc.M007635200. PMID 10988299.
Lyons RJ, Deane R, Lynch DK, et al. (2001). "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14.". J. Biol. Chem. 276 (20): 17172-80. doi:10.1074/jbc.M009756200. PMID 11278563.
Kim BY, Krämer H, Yamamoto A, et al. (2001). "Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7.". J. Biol. Chem. 276 (31): 29393-402. doi:10.1074/jbc.M101778200. PMID 11382755.
Cook BD, Dynek JN, Chang W, et al. (2002). "Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres.". Mol. Cell. Biol. 22 (1): 332-42. PMID 11739745.
Sbodio JI, Lodish HF, Chi NW (2002). "Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase).". Biochem. J. 361 (Pt 3): 451-9. PMID 11802774.
Seimiya H, Smith S (2002). "The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182).". J. Biol. Chem. 277 (16): 14116-26. doi:10.1074/jbc.M112266200. PMID 11854288.
Sbodio JI, Chi NW (2002). "Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner.". J. Biol. Chem. 277 (35): 31887-92. doi:10.1074/jbc.M203916200. PMID 12080061.
Rippmann JF, Damm K, Schnapp A (2002). "Functional characterization of the poly(ADP-ribose) polymerase activity of tankyrase 1, a potential regulator of telomere length.". J. Mol. Biol. 323 (2): 217-24. PMID 12381316.
Bae J, Donigian JR, Hsueh AJ (2003). "Tankyrase 1 interacts with Mcl-1 proteins and inhibits their regulation of apoptosis.". J. Biol. Chem. 278 (7): 5195-204. doi:10.1074/jbc.M201988200. PMID 12475993.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Loayza D, De Lange T (2003). "POT1 as a terminal transducer of TRF1 telomere length control.". Nature 423 (6943): 1013-8. doi:10.1038/nature01688. PMID 12768206.
Fuchs U, Rehkamp GF, Slany R, et al. (2003). "The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance.". FEBS Lett. 554 (1-2): 10-6. PMID 14596906.
Seimiya H, Muramatsu Y, Smith S, Tsuruo T (2004). "Functional subdomain in the ankyrin domain of tankyrase 1 required for poly(ADP-ribosyl)ation of TRF1 and telomere elongation.". Mol. Cell. Biol. 24 (5): 1944-55. PMID 14966275.
Dynek JN, Smith S (2004). "Resolution of sister telomere association is required for progression through mitosis.". Science 304 (5667): 97-100. doi:10.1126/science.1094754. PMID 15064417.
Ye JZ, de Lange T (2004). "TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex.". Nat. Genet. 36 (6): 618-23. doi:10.1038/ng1360. PMID 15133513.