TNKS2

From Wikipedia, the free encyclopedia

Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2

Identifiers

TNKS2; PARP-5b; PARP-5c; PARP5B; PARP5C; TANK2; TNKL

External IDs

OMIM: 607128 MGI: 1921743 HomoloGene: 11890

Gene ontology
Molecular Function:	• NAD+ ADP-ribosyltransferase activity • transferase activity, transferring glycosyl groups
Cellular Component:	• chromosome, telomeric region • nucleus • chromosome
Biological Process:	• protein amino acid ADP-ribosylation • regulation of body size

Orthologs

Human

Mouse

n/a

Refseq

NM_025235 (mRNA)
NP_079511 (protein)

XM_001000101 (mRNA)
XP_001000101 (protein)

Location

Chr 10: 93.55 - 93.62 Mb

Chr 19: 36.9 - 36.96 Mb

Pubmed search

[1]

[2]

Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, also known as TNKS2, is a human gene.^[1]

[edit] References

^ Entrez Gene: TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2.

[edit] Further reading

Monz D, Munnia A, Comtesse N, et al. (2001). "Novel tankyrase-related gene detected with meningioma-specific sera.". Clin. Cancer Res. 7 (1): 113-9. PMID 11205898.
Lyons RJ, Deane R, Lynch DK, et al. (2001). "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14.". J. Biol. Chem. 276 (20): 17172-80. doi:10.1074/jbc.M009756200. PMID 11278563.
Kuimov AN, Kuprash DV, Petrov VN, et al. (2001). "Cloning and characterization of TNKL, a member of tankyrase gene family.". Genes Immun. 2 (1): 52-5. doi:10.1038/sj.gene.6363722. PMID 11294570.
Kaminker PG, Kim SH, Taylor RD, et al. (2001). "TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression.". J. Biol. Chem. 276 (38): 35891-9. doi:10.1074/jbc.M105968200. PMID 11454873.
Cook BD, Dynek JN, Chang W, et al. (2002). "Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres.". Mol. Cell. Biol. 22 (1): 332-42. PMID 11739745.
Sbodio JI, Lodish HF, Chi NW (2002). "Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase).". Biochem. J. 361 (Pt 3): 451-9. PMID 11802774.
Seimiya H, Smith S (2002). "The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182).". J. Biol. Chem. 277 (16): 14116-26. doi:10.1074/jbc.M112266200. PMID 11854288.
Sbodio JI, Chi NW (2002). "Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner.". J. Biol. Chem. 277 (35): 31887-92. doi:10.1074/jbc.M203916200. PMID 12080061.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375-81. doi:10.1038/nature02462. PMID 15164054.
Deng Z, Atanasiu C, Zhao K, et al. (2005). "Inhibition of Epstein-Barr virus OriP function by tankyrase, a telomere-associated poly-ADP ribose polymerase that binds and modifies EBNA1.". J. Virol. 79 (8): 4640-50. doi:10.1128/JVI.79.8.4640-4650.2005. PMID 15795250.
Sidorova N, Zavalishina L, Kurchashova S, et al. (2006). "Immunohistochemical detection of tankyrase 2 in human breast tumors and normal renal tissue.". Cell Tissue Res. 323 (1): 137-45. doi:10.1007/s00441-005-0053-8. PMID 16151859.