TNIP2

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TNFAIP3 interacting protein 2
Identifiers
Symbol(s) TNIP2; ABIN-2; ABIN2; FLIP1; KLIP; MGC4289
External IDs OMIM: 610669 MGI: 2386643 HomoloGene: 11515
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 79155 231130
Ensembl ENSG00000168884 ENSMUSG00000059866
Refseq NM_024309 (mRNA)
NP_077285 (protein)		 NM_139064 (mRNA)
NP_620703 (protein)
Location Chr 4: 2.71 - 2.73 Mb Chr 5: 34.81 - 34.83 Mb
Pubmed search [1] [2]

TNFAIP3 interacting protein 2, also known as TNIP2, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: TNIP2 TNFAIP3 interacting protein 2.

[edit] Further reading

  • Heyninck K, De Valck D, Vanden Berghe W, et al. (1999). "The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN.". J. Cell Biol. 145 (7): 1471-82. PMID 10385526. 
  • Klinkenberg M, Van Huffel S, Heyninck K, Beyaert R (2001). "Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions.". FEBS Lett. 498 (1): 93-7. PMID 11389905. 
  • Van Huffel S, Delaei F, Heyninck K, et al. (2001). "Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2.". J. Biol. Chem. 276 (32): 30216-23. doi:10.1074/jbc.M100048200. PMID 11390377. 
  • Wu WS, Xu ZX, Chang KS (2002). "The promyelocytic leukemia protein represses A20-mediated transcription.". J. Biol. Chem. 277 (35): 31734-9. doi:10.1074/jbc.M201648200. PMID 12080044. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Liu WK, Chien CY, Chou CK, Su JY (2003). "An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation.". J. Biomed. Sci. 10 (2): 242-52. doi:10.1159/000068708. PMID 12595760. 
  • Hughes DP, Marron MB, Brindle NP (2003). "The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2.". Circ. Res. 92 (6): 630-6. doi:10.1161/01.RES.0000063422.38690.DC. PMID 12609966. 
  • Chien CY, Liu WK, Chou CK, Su JY (2003). "The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation.". FEBS Lett. 543 (1-3): 55-60. PMID 12753905. 
  • Tadros A, Hughes DP, Dunmore BJ, Brindle NP (2004). "ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1.". Blood 102 (13): 4407-9. doi:10.1182/blood-2003-05-1602. PMID 12933576. 
  • Liu WK, Yen PF, Chien CY, et al. (2004). "The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis.". Biochem. J. 378 (Pt 3): 867-76. doi:10.1042/BJ20031736. PMID 14653779. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97-105. doi:10.1038/ncb1086. PMID 14743216. 
  • Lang V, Symons A, Watton SJ, et al. (2004). "ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability.". Mol. Cell. Biol. 24 (12): 5235-48. doi:10.1128/MCB.24.12.5235-5248.2004. PMID 15169888. 
  • Li CC, Chou CK, Wang MH, Tsai TF (2006). "Overexpression of ABIN-2, a negative regulator of NF-kappaB, delays liver regeneration in the ABIN-2 transgenic mice.". Biochem. Biophys. Res. Commun. 342 (1): 300-9. doi:10.1016/j.bbrc.2006.01.114. PMID 16480954. 
  • Greenberg H, Ye X, Wilson D, et al. (2006). "Chronic intermittent hypoxia activates nuclear factor-kappaB in cardiovascular tissues in vivo.". Biochem. Biophys. Res. Commun. 343 (2): 591-6. doi:10.1016/j.bbrc.2006.03.015. PMID 16554025. 
  • Liu Y, Nakahara T, Miyakoshi J, et al. (2007). "Nuclear accumulation and activation of nuclear factor kappaB after split-dose irradiation in LS174T cells.". J. Radiat. Res. 48 (1): 13-20. PMID 17038805. 
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