TNFSF12

From Wikipedia, the free encyclopedia

Tumor necrosis factor (ligand) superfamily, member 12

Identifiers

TNFSF12; APO3L; DR3LG; MGC129581; MGC20669; TWEAK

External IDs

OMIM: 602695 MGI: 1196259 HomoloGene: 7979

Gene ontology
Molecular Function:	• cytokine activity • tumor necrosis factor receptor binding
Cellular Component:	• extracellular space • integral to plasma membrane • membrane • perinuclear region of cytoplasm
Biological Process:	• angiogenesis • positive regulation of endothelial cell proliferation • apoptosis • induction of apoptosis • immune response • signal transduction • multicellular organismal development • cell differentiation • endothelial cell migration • positive regulation of angiogenesis

Orthologs

Human

Mouse

Entrez

8742

21944

Refseq

NM_003809 (mRNA)
NP_003800 (protein)

XM_994516 (mRNA)
XP_999610 (protein)

Pubmed search

[1]

[2]

Tumor necrosis factor (ligand) superfamily, member 12, also known as TNFSF12, is a human gene.^[1]

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis.^[1]

[edit] References

^ ^a ^b Entrez Gene: TNFSF12 tumor necrosis factor (ligand) superfamily, member 12.

[edit] Further reading

Wiley SR, Winkles JA (2004). "TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor.". Cytokine Growth Factor Rev. 14 (3-4): 241–9. PMID 12787562.
Campbell S, Michaelson J, Burkly L, Putterman C (2006). "The role of TWEAK/Fn14 in the pathogenesis of inflammation and systemic autoimmunity.". Front. Biosci. 9: 2273–84. PMID 15353286.
Chicheportiche Y, Bourdon PR, Xu H, et al. (1998). "TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis.". J. Biol. Chem. 272 (51): 32401–10. PMID 9405449.
Marsters SA, Sheridan JP, Pitti RM, et al. (1998). "Identification of a ligand for the death-domain-containing receptor Apo3.". Curr. Biol. 8 (9): 525–8. PMID 9560343.
Lynch CN, Wang YC, Lund JK, et al. (1999). "TWEAK induces angiogenesis and proliferation of endothelial cells.". J. Biol. Chem. 274 (13): 8455–9. PMID 10085077.
Kaplan MJ, Ray D, Mo RR, et al. (2000). "TRAIL (Apo2 ligand) and TWEAK (Apo3 ligand) mediate CD4+ T cell killing of antigen-presenting macrophages.". J. Immunol. 164 (6): 2897–904. PMID 10706675.
Kaptein A, Jansen M, Dilaver G, et al. (2000). "Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3).". FEBS Lett. 485 (2-3): 135–41. PMID 11094155.
Wiley SR, Cassiano L, Lofton T, et al. (2001). "A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis.". Immunity 15 (5): 837–46. PMID 11728344.
Nakayama M, Ishidoh K, Kayagaki N, et al. (2002). "Multiple pathways of TWEAK-induced cell death.". J. Immunol. 168 (2): 734–43. PMID 11777967.
Jakubowski A, Browning B, Lukashev M, et al. (2002). "Dual role for TWEAK in angiogenic regulation.". J. Cell. Sci. 115 (Pt 2): 267–74. PMID 11839778.
Kaplan MJ, Lewis EE, Shelden EA, et al. (2003). "The apoptotic ligands TRAIL, TWEAK, and Fas ligand mediate monocyte death induced by autologous lupus T cells.". J. Immunol. 169 (10): 6020–9. PMID 12421989.
Harada N, Nakayama M, Nakano H, et al. (2003). "Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells.". Biochem. Biophys. Res. Commun. 299 (3): 488–93. PMID 12445828.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Nakayama M, Ishidoh K, Kojima Y, et al. (2003). "Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death.". J. Immunol. 170 (1): 341–8. PMID 12496418.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Tian XL, Kadaba R, You SA, et al. (2004). "Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome.". Nature 427 (6975): 640–5. doi:10.1038/nature02320. PMID 14961121.
Kim SH, Kang YJ, Kim WJ, et al. (2004). "TWEAK can induce pro-inflammatory cytokines and matrix metalloproteinase-9 in macrophages.". Circ. J. 68 (4): 396–9. PMID 15056843.
Jin L, Nakao A, Nakayama M, et al. (2004). "Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes.". J. Invest. Dermatol. 122 (5): 1175–9. doi:10.1111/j.0022-202X.2004.22419.x. PMID 15140220.