TNFAIP3

From Wikipedia, the free encyclopedia

Tumor necrosis factor, alpha-induced protein 3

Identifiers

TNFAIP3; A20; MGC104522; MGC138687; MGC138688; OTUD7C; TNFA1P2

External IDs

OMIM: 191163 MGI: 1196377 HomoloGene: 4582

Gene ontology
Molecular Function:	• DNA binding • protein binding • cysteine-type peptidase activity • zinc ion binding • metal ion binding
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• ubiquitin cycle • apoptosis • anti-apoptosis • negative regulation of I-kappaB kinase/NF-kappaB cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006290 (mRNA)
NP_006281 (protein)

NM_009397 (mRNA)
NP_033423 (protein)

Location

Chr 6: 138.23 - 138.25 Mb

Chr 10: 18.69 - 18.7 Mb

Pubmed search

[1]

[2]

Tumor necrosis factor, alpha-induced protein 3, also known as TNFAIP3, is a human gene.^[1]

This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. Knockout studies of a similar gene in mice suggested that this gene is critical for limiting inflammation by terminating TNF-induced NF-kappa B responses.^[1]

[edit] References

^ ^a ^b Entrez Gene: TNFAIP3 tumor necrosis factor, alpha-induced protein 3.

[edit] Further reading

Opipari AW, Boguski MS, Dixit VM (1990). "The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein.". J. Biol. Chem. 265 (25): 14705–8. PMID 2118515.
Dixit VM, Green S, Sarma V, et al. (1990). "Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin.". J. Biol. Chem. 265 (5): 2973–8. PMID 2406243.
Cooper JT, Stroka DM, Brostjan C, et al. (1996). "A20 blocks endothelial cell activation through a NF-kappaB-dependent mechanism.". J. Biol. Chem. 271 (30): 18068–73. PMID 8663499.
Song HY, Rothe M, Goeddel DV (1996). "The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation.". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6721–5. PMID 8692885.
Vincenz C, Dixit VM (1996). "14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules.". J. Biol. Chem. 271 (33): 20029–34. PMID 8702721.
De Valck D, Heyninck K, Van Criekinge W, et al. (1996). "A20, an inhibitor of cell death, self-associates by its zinc finger domain.". FEBS Lett. 384 (1): 61–4. PMID 8797804.
De Valck D, Heyninck K, Van Criekinge W, et al. (1997). "A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins.". Biochem. Biophys. Res. Commun. 238 (2): 590–4. doi:10.1006/bbrc.1997.7343. PMID 9299557.
Eliopoulos AG, Blake SM, Floettmann JE, et al. (1999). "Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C terminus via a mechanism involving TRADD and TRAF2.". J. Virol. 73 (2): 1023–35. PMID 9882303.
Heyninck K, Beyaert R (1999). "The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6.". FEBS Lett. 442 (2-3): 147–50. PMID 9928991.
Heyninck K, De Valck D, Vanden Berghe W, et al. (1999). "The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN.". J. Cell Biol. 145 (7): 1471–82. PMID 10385526.
De Valck D, Jin DY, Heyninck K, et al. (1999). "The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases.". Oncogene 18 (29): 4182–90. doi:10.1038/sj.onc.1202787. PMID 10435631.
Zhang SQ, Kovalenko A, Cantarella G, Wallach D (2000). "Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation.". Immunity 12 (3): 301–11. PMID 10755617.
Lee EG, Boone DL, Chai S, et al. (2000). "Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice.". Science 289 (5488): 2350–4. PMID 11009421.
Klinkenberg M, Van Huffel S, Heyninck K, Beyaert R (2001). "Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions.". FEBS Lett. 498 (1): 93–7. PMID 11389905.
Van Huffel S, Delaei F, Heyninck K, et al. (2001). "Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2.". J. Biol. Chem. 276 (32): 30216–23. doi:10.1074/jbc.M100048200. PMID 11390377.
Evans PC, Taylor ER, Coadwell J, et al. (2001). "Isolation and characterization of two novel A20-like proteins.". Biochem. J. 357 (Pt 3): 617–23. PMID 11463333.
Baltathakis I, Alcantara O, Boldt DH (2001). "Expression of different NF-kappaB pathway genes in dendritic cells (DCs) or macrophages assessed by gene expression profiling.". J. Cell. Biochem. 83 (2): 281–90. PMID 11573245.
Zetoune FS, Murthy AR, Shao Z, et al. (2002). "A20 inhibits NF-kappa B activation downstream of multiple Map3 kinases and interacts with the I kappa B signalosome.". Cytokine 15 (6): 282–98. doi:10.1006/cyto.2001.0921. PMID 11594795.
Wu WS, Xu ZX, Chang KS (2002). "The promyelocytic leukemia protein represses A20-mediated transcription.". J. Biol. Chem. 277 (35): 31734–9. doi:10.1074/jbc.M201648200. PMID 12080044.
He KL, Ting AT (2002). "A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells.". Mol. Cell. Biol. 22 (17): 6034–45. PMID 12167698.