TMEM158

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Transmembrane protein 158
Identifiers
Symbol(s) TMEM158; BBP; RIS1; DKFZp586E1621; p40BBP
External IDs MGI: 1919559 HomoloGene: 9141
Orthologs
Human Mouse
Entrez 25907 72309
Ensembl n/a ENSMUSG00000054871
Refseq NM_015444 (mRNA)
NP_056259 (protein)		 NM_001002267 (mRNA)
NP_001002267 (protein)
Location n/a Chr 9: 123.11 - 123.11 Mb
Pubmed search [1] [2]

Transmembrane protein 158, also known as TMEM158, is a human gene.[1]

Constitutive activation of the Ras pathway triggers an irreversible proliferation arrest reminiscent of replicative senescence. Transcription of this gene is upregulated in response to activation of the Ras pathway, but not under other conditions that induce senescence. The encoded protein is similar to a rat cell surface receptor proposed to function in a neuronal survival pathway.[1]

[edit] References

  1. ^ a b Entrez Gene: TMEM158 transmembrane protein 158.

[edit] Further reading

  • Iglesias D, Fernández-Peralta AM, Nejda N, et al. (2006). "RIS1, a gene with trinucleotide repeats, is a target in the mutator pathway of colorectal carcinogenesis.". Cancer Genet. Cytogenet. 167 (2): 138–44. doi:10.1016/j.cancergencyto.2005.12.002. PMID 16737913. 
  • Zirn B, Samans B, Wittmann S, et al. (2006). "Target genes of the WNT/beta-catenin pathway in Wilms tumors.". Genes Chromosomes Cancer 45 (6): 565–74. doi:10.1002/gcc.20319. PMID 16575872. 
  • Silva J, Silva JM, Barradas M, et al. (2006). "Analysis of the candidate tumor suppressor Ris-1 in primary human breast carcinomas.". Mutat. Res. 594 (1-2): 78–85. doi:10.1016/j.mrfmmm.2005.07.017. PMID 16280139. 
  • Sussan TE, Pletcher MT, Murakami Y, Reeves RH (2006). "Tumor suppressor in lung cancer 1 (TSLC1) alters tumorigenic growth properties and gene expression.". Mol. Cancer 4: 28. doi:10.1186/1476-4598-4-28. PMID 16083501. 
  • Verlinden I, Janssens J, Raus J, Michiels L (2005). "Microdissection and SAGE as a combined tool to reveal gene expression in ductal carcinoma in situ of the breast.". Mol. Carcinog. 41 (4): 197–206. doi:10.1002/mc.20055. PMID 15486950. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Barradas M, Gonos ES, Zebedee Z, et al. (2002). "Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence.". Exp. Cell Res. 273 (2): 127–37. doi:10.1006/excr.2001.5434. PMID 11822868. 
  • Hama T, Maruyama M, Katoh-Semba R, et al. (2001). "Identification and molecular cloning of a novel brain-specific receptor protein that binds to brain injury-derived neurotrophic peptide. Possible role for neuronal survival.". J. Biol. Chem. 276 (34): 31929–35. doi:10.1074/jbc.M100617200. PMID 11399754. 
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