TMED2

From Wikipedia, the free encyclopedia

Transmembrane emp24 domain trafficking protein 2

Identifiers

TMED2; FLJ21323; P24A; RNP24

External IDs

MGI: 1929269 HomoloGene: 55991

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• microsome • ER-Golgi intermediate compartment • plasma membrane • integral to membrane • zymogen granule membrane
Biological Process:	• intracellular protein transport • ER to Golgi vesicle-mediated transport • vesicle targeting

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006815 (mRNA)
NP_006806 (protein)

NM_019770 (mRNA)
NP_062744 (protein)

Location

Chr 12: 122.64 - 122.65 Mb

Chr 5: 124.8 - 124.81 Mb

Pubmed search

[1]

[2]

Transmembrane emp24 domain trafficking protein 2, also known as TMED2, is a human gene.^[1]

[edit] References

^ Entrez Gene: TMED2 transmembrane emp24 domain trafficking protein 2.

[edit] Further reading

Blum R, Feick P, Puype M, et al. (1996). "Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking.". J. Biol. Chem. 271 (29): 17183-9. PMID 8663407.
Fiedler K, Veit M, Stamnes MA, Rothman JE (1996). "Bimodal interaction of coatomer with the p24 family of putative cargo receptors.". Science 273 (5280): 1396-9. PMID 8703076.
Gommel D, Orci L, Emig EM, et al. (1999). "p24 and p23, the major transmembrane proteins of COPI-coated transport vesicles, form hetero-oligomeric complexes and cycle between the organelles of the early secretory pathway.". FEBS Lett. 447 (2-3): 179-85. PMID 10214941.
Majoul I, Straub M, Hell SW, et al. (2001). "KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET.". Dev. Cell 1 (1): 139-53. PMID 11703931.
Barr FA, Preisinger C, Kopajtich R, Körner R (2002). "Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus.". J. Cell Biol. 155 (6): 885-91. doi:10.1083/jcb.200108102. PMID 11739402.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Breuza L, Halbeisen R, Jenö P, et al. (2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46.". J. Biol. Chem. 279 (45): 47242-53. doi:10.1074/jbc.M406644200. PMID 15308636.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Chen F, Hasegawa H, Schmitt-Ulms G, et al. (2006). "TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.". Nature 440 (7088): 1208-12. doi:10.1038/nature04667. PMID 16641999.
Luo W, Wang Y, Reiser G (2007). "p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking.". J. Biol. Chem. 282 (41): 30246-55. doi:10.1074/jbc.M703205200. PMID 17693410.