TM4SF1

From Wikipedia, the free encyclopedia

Transmembrane 4 L six family member 1

Identifiers

TM4SF1; H-L6; L6; M3S1; TAAL6

External IDs

OMIM: 191155 MGI: 104678 HomoloGene: 7409

Gene ontology
Molecular Function:	• molecular_function
Cellular Component:	• integral to plasma membrane • membrane • integral to membrane
Biological Process:	• biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014220 (mRNA)
NP_055035 (protein)

NM_008536 (mRNA)
NP_032562 (protein)

Location

Chr 3: 150.57 - 150.58 Mb

Chr 3: 57.38 - 57.38 Mb

Pubmed search

[1]

[2]

Transmembrane 4 L six family member 1, also known as TM4SF1, is a human gene.^[1]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas.^[1]

[edit] References

^ ^a ^b Entrez Gene: TM4SF1 transmembrane 4 L six family member 1.

[edit] Further reading

Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye.". J. Cell. Sci. 114 (Pt 23): 4143–51. PMID 11739647.
Marken JS, Schieven GL, Hellström I, et al. (1992). "Cloning and expression of the tumor-associated antigen L6.". Proc. Natl. Acad. Sci. U.S.A. 89 (8): 3503–7. PMID 1565644.
Marken JS, Bajorath J, Edwards CP, et al. (1994). "Membrane topology of the L6 antigen and identification of the protein epitope recognized by the L6 monoclonal antibody.". J. Biol. Chem. 269 (10): 7397–401. PMID 7510285.
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
Virtaneva KI, Emi N, Marken JS, et al. (1994). "Chromosomal localization of three human genes coding for A15, L6, and S5.7 (TAPA1): all members of the transmembrane 4 superfamily of proteins.". Immunogenetics 39 (5): 329–34. PMID 8168850.
Borrell-Pagès M, Fernández-Larrea J, Borroto A, et al. (2001). "The carboxy-terminal cysteine of the tetraspanin L6 antigen is required for its interaction with SITAC, a novel PDZ protein.". Mol. Biol. Cell 11 (12): 4217–25. PMID 11102519.
Storim J, Friedl P, Schaefer BM, et al. (2001). "Molecular and functional characterization of the four-transmembrane molecule l6 in epidermal keratinocytes.". Exp. Cell Res. 267 (2): 233–42. doi:10.1006/excr.2001.5250. PMID 11426942.
Kaneko R, Tsuji N, Kamagata C, et al. (2002). "Amount of expression of the tumor-associated antigen L6 gene and transmembrane 4 superfamily member 5 gene in gastric cancers and gastric mucosa.". Am. J. Gastroenterol. 96 (12): 3457–8. PMID 11774983.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Kao YR, Shih JY, Wen WC, et al. (2004). "Tumor-associated antigen L6 and the invasion of human lung cancer cells.". Clin. Cancer Res. 9 (7): 2807–16. PMID 12855661.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Chang YW, Chen SC, Cheng EC, et al. (2005). "CD13 (aminopeptidase N) can associate with tumor-associated antigen L6 and enhance the motility of human lung cancer cells.". Int. J. Cancer 116 (2): 243–52. doi:10.1002/ijc.21089. PMID 15812828.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.