TLK2

From Wikipedia, the free encyclopedia

Tousled-like kinase 2

Identifiers

TLK2; MGC44450; PKU-ALPHA

External IDs

OMIM: 608439 MGI: 1346023 HomoloGene: 4993

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • ATP binding • transferase activity
Cellular Component:	• nucleus
Biological Process:	• regulation of chromatin assembly or disassembly • protein amino acid phosphorylation • response to DNA damage stimulus • cell cycle • intracellular signaling cascade • chromatin modification

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006852 (mRNA)
NP_006843 (protein)

NM_011903 (mRNA)
NP_036033 (protein)

Location

Chr 17: 57.89 - 58.04 Mb

Chr 11: 105 - 105.1 Mb

Pubmed search

[1]

[2]

Tousled-like kinase 2, also known as TLK2, is a human gene.^[1]

The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: TLK2 tousled-like kinase 2.

[edit] Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Yamakawa A, Kameoka Y, Hashimoto K, et al. (1998). "cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal.". Gene 202 (1-2): 193-201. PMID 9427565.
Zhang S, Xing H, Muslin AJ (1999). "Nuclear localization of protein kinase U-alpha is regulated by 14-3-3.". J. Biol. Chem. 274 (35): 24865-72. PMID 10455159.
Silljé HH, Takahashi K, Tanaka K, et al. (1999). "Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication.". EMBO J. 18 (20): 5691-702. doi:10.1093/emboj/18.20.5691. PMID 10523312.
Silljé HH, Nigg EA (2001). "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases.". Curr. Biol. 11 (13): 1068-73. PMID 11470414.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Groth A, Lukas J, Nigg EA, et al. (2003). "Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint.". EMBO J. 22 (7): 1676-87. doi:10.1093/emboj/cdg151. PMID 12660173.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.