TLE3

From Wikipedia, the free encyclopedia


Transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
PDB rendering based on 1gxr.
Available structures: 1gxr, 2ce8, 2ce9
Identifiers
Symbol(s) TLE3; ESG; ESG3; FLJ39460; GRG3; HsT18976; KIAA1547
External IDs OMIM: 600190 MGI: 104634 HomoloGene: 21059
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 7090 21887
Ensembl ENSG00000140332 ENSMUSG00000032280
Uniprot Q04726 Q3TY99
Refseq NM_005078 (mRNA)
NP_005069 (protein)		 XM_001003585 (mRNA)
XP_001003585 (protein)
Location Chr 15: 68.13 - 68.18 Mb Chr 9: 61.17 - 61.22 Mb
Pubmed search [1] [2]

Transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila), also known as TLE3, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: TLE3 transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila).

[edit] Further reading

  • Stifani S, Blaumueller CM, Redhead NJ, et al. (1993). "Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins.". Nat. Genet. 2 (2): 119–27. doi:10.1038/ng1092-119. PMID 1303260. 
  • Miyasaka H, Choudhury BK, Hou EW, Li SS (1993). "Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein.". Eur. J. Biochem. 216 (1): 343–52. PMID 8365415. 
  • Liu Y, Dehni G, Purcell KJ, et al. (1996). "Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia.". Genomics 31 (1): 58–64. doi:10.1006/geno.1996.0009. PMID 8808280. 
  • Wang JC, Waltner-Law M, Yamada K, et al. (2000). "Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta.". J. Biol. Chem. 275 (24): 18418–23. doi:10.1074/jbc.M910211199. PMID 10748198. 
  • Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (4): 273–81. PMID 10997877. 
  • Yao J, Lai E, Stifani S (2001). "The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription.". Mol. Cell. Biol. 21 (6): 1962–72. doi:10.1128/MCB.21.6.1962-1972.2001. PMID 11238932. 
  • Nuthall HN, Joachim K, Palaparti A, Stifani S (2003). "A role for cell cycle-regulated phosphorylation in Groucho-mediated transcriptional repression.". J. Biol. Chem. 277 (52): 51049–57. doi:10.1074/jbc.M111660200. PMID 12397081. 
  • López-Ríos J, Tessmar K, Loosli F, et al. (2003). "Six3 and Six6 activity is modulated by members of the groucho family.". Development 130 (1): 185–95. PMID 12441302. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. 
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
  • Tu LC, Yan X, Hood L, Lin B (2007). "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells.". Mol. Cell Proteomics 6 (4): 575–88. doi:10.1074/mcp.M600249-MCP200. PMID 17220478. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
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