Image:Tissue factor activation.png

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Description

Tissue Factor (PDB code: 1dan) starts a cascade that leads to the formation of a clot. Factor VII binds to tissue factor becoming almost 1000 times more active. Factor VII then activate factor X, which activates prothrombin to thrombin. Thrombin activates fibrinogen to fibrin, that binds platelets together forming the clot (extrinisic pathway).

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Source

Molecule of the Month by www.pdb.org (see the Molecule of the Month section for more details]

Date

Year 2006 (see the complete list for more details)

Author

Illustration by David S. Goodsell of The Scripps Research Institute (see this site)

Permission
(Reusing this image)

Original work of the US Federal Government - public domain


Public domain This work is in the public domain in the United States because it is a work of the United States Federal Government under the terms of Title 17, Chapter 1, Section 105 of the US Code. See Copyright.

Note: This only applies to works of the Federal Government and not to the work of any individual U.S. state, territory, commonwealth, county, municipality, or any other subdivision.


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current16:02, 23 September 2006542×600 (69 KB)Giac83 ({{Information| |Description=Tissue Factor (PDB code: 1dan) starts a cascade that leads to the formation of a clot. Factor VII binds to tissue factor becoming almost 1000 times more active. Factor VII then activate factor X, which activates prothrombin to )
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