TINF2

From Wikipedia, the free encyclopedia

TERF1 (TRF1)-interacting nuclear factor 2

Identifiers

External IDs

OMIM: 604319 MGI: 107246 HomoloGene: 8264

Gene ontology
Molecular Function:	• DNA binding • protein binding • telomeric DNA binding
Cellular Component:	• chromosome, telomeric region • nucleus • chromosome
Biological Process:	• telomere maintenance via telomerase

Orthologs

Human

Mouse

Refseq

NM_012461 (mRNA)
NP_036593 (protein)

NM_145705 (mRNA)
NP_663751 (protein)

Location

Chr 14: 23.78 - 23.78 Mb

Chr 14: 54.63 - 54.64 Mb

Pubmed search

[1]

[2]

TERF1 (TRF1)-interacting nuclear factor 2, also known as TINF2, is a human gene.^[1]

[edit] References

^ Entrez Gene: TINF2 TERF1 (TRF1)-interacting nuclear factor 2.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Kim SH, Kaminker P, Campisi J (1999). "TIN2, a new regulator of telomere length in human cells.". Nat. Genet. 23 (4): 405–12. doi:10.1038/70508. PMID 10581025.
Li B, Oestreich S, de Lange T (2000). "Identification of human Rap1: implications for telomere evolution.". Cell 101 (5): 471–83. PMID 10850490.
Mignon-Ravix C, Depetris D, Delobel B, et al. (2002). "A human interstitial telomere associates in vivo with specific TRF2 and TIN2 proteins.". Eur. J. Hum. Genet. 10 (2): 107–12. doi:10.1038/sj.ejhg.5200775. PMID 11938440.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Yamada M, Tsuji N, Nakamura M, et al. (2003). "Down-regulation of TRF1, TRF2 and TIN2 genes is important to maintain telomeric DNA for gastric cancers.". Anticancer Res. 22 (6A): 3303–7. PMID 12530079.
Loayza D, De Lange T (2003). "POT1 as a terminal transducer of TRF1 telomere length control.". Nature 423 (6943): 1013–8. doi:10.1038/nature01688. PMID 12768206.
Kim SH, Han S, You YH, et al. (2004). "The human telomere-associated protein TIN2 stimulates interactions between telomeric DNA tracts in vitro.". EMBO Rep. 4 (7): 685–91. doi:10.1038/sj.embor.embor872. PMID 12835755.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Loayza D, Parsons H, Donigian J, et al. (2004). "DNA binding features of human POT1: a nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites.". J. Biol. Chem. 279 (13): 13241–8. doi:10.1074/jbc.M312309200. PMID 14715659.
Ye JZ, de Lange T (2004). "TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex.". Nat. Genet. 36 (6): 618–23. doi:10.1038/ng1360. PMID 15133513.
Liu D, Safari A, O'Connor MS, et al. (2004). "PTOP interacts with POT1 and regulates its localization to telomeres.". Nat. Cell Biol. 6 (7): 673–80. doi:10.1038/ncb1142. PMID 15181449.
Ye JZ, Hockemeyer D, Krutchinsky AN, et al. (2004). "POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex.". Genes Dev. 18 (14): 1649–54. doi:10.1101/gad.1215404. PMID 15231715.
Kim SH, Beausejour C, Davalos AR, et al. (2004). "TIN2 mediates functions of TRF2 at human telomeres.". J. Biol. Chem. 279 (42): 43799–804. doi:10.1074/jbc.M408650200. PMID 15292264.
Ye JZ, Donigian JR, van Overbeek M, et al. (2004). "TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.". J. Biol. Chem. 279 (45): 47264–71. doi:10.1074/jbc.M409047200. PMID 15316005.
Liu D, O'Connor MS, Qin J, Songyang Z (2005). "Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins.". J. Biol. Chem. 279 (49): 51338–42. doi:10.1074/jbc.M409293200. PMID 15383534.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Oh BK, Kim YJ, Park C, Park YN (2005). "Up-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesis.". Am. J. Pathol. 166 (1): 73–80. PMID 15632001.
Kaminker P, Plachot C, Kim SH, et al. (2005). "Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2.". J. Cell. Sci. 118 (Pt 6): 1321–30. doi:10.1242/jcs.01709. PMID 15741234.