TINAG

From Wikipedia, the free encyclopedia

Tubulointerstitial nephritis antigen

Identifiers

TINAG; TIN1; TIN2; TIN-AG

External IDs

OMIM: 606749 MGI: 1349477 HomoloGene: 8082

Gene ontology
Molecular Function:	• nucleotide binding • cysteine-type endopeptidase activity • protein binding
Cellular Component:	• basement membrane
Biological Process:	• proteolysis • cell adhesion • Malpighian tubule morphogenesis

Orthologs

Human

Mouse

n/a

Refseq

NM_014464 (mRNA)
NP_055279 (protein)

NM_012033 (mRNA)
NP_036163 (protein)

Location

Chr 6: 54.28 - 54.36 Mb

Chr 9: 76.74 - 76.83 Mb

Pubmed search

[1]

[2]

Tubulointerstitial nephritis antigen, also known as TINAG, is a human gene.^[1]

TINAG is a basement membrane glycoprotein initially identified as a target of antibodies in some forms of immunologically mediated tubulointerstitial nephritis.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: TINAG tubulointerstitial nephritis antigen.

[edit] Further reading

Katz A, Fish AJ, Santamaria P, et al. (1993). "Role of antibodies to tubulointerstitial nephritis antigen in human anti-tubular basement membrane nephritis associated with membranous nephropathy.". Am. J. Med. 93 (6): 691–8. PMID 1466368.
Butkowski RJ, Kleppel MM, Katz A, et al. (1992). "Distribution of tubulointerstitial nephritis antigen and evidence for multiple forms.". Kidney Int. 40 (5): 838–46. PMID 1762287.
Fliger FD, Wieslander J, Brentjens JR, et al. (1987). "Identification of a target antigen in human anti-tubular basement membrane nephritis.". Kidney Int. 31 (3): 800–7. PMID 3553704.
Chen Y, Krishnamurti U, Wayner EA, et al. (1996). "REceptors in proximal tubular epithelial cells for tubulointerstitial nephritis antigen.". Kidney Int. 49 (1): 153–7. PMID 8770961.
Nelson TR, Kim Y, Michael AF, et al. (1999). "Tubulointerstitial nephritis antigen (TIN-ag) is expressed in distinct segments of the developing human nephron.". Connect. Tissue Res. 37 (1-2): 53–60. PMID 9643646.
Kim SH, Kaminker P, Campisi J (1999). "TIN2, a new regulator of telomere length in human cells.". Nat. Genet. 23 (4): 405–12. doi:10.1038/70508. PMID 10581025.
Ikeda M, Takemura T, Hino S, Yoshioka K (2000). "Molecular cloning, expression, and chromosomal localization of a human tubulointerstitial nephritis antigen.". Biochem. Biophys. Res. Commun. 268 (1): 225–30. doi:10.1006/bbrc.2000.2103. PMID 10652240.
Zhou B, Nelson TR, Kashtan C, et al. (2000). "Identification of two alternatively spliced forms of human tubulointerstitial nephritis antigen (TIN-Ag).". J. Am. Soc. Nephrol. 11 (4): 658–68. PMID 10752525.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.