TIMP4

From Wikipedia, the free encyclopedia

TIMP metallopeptidase inhibitor 4

Identifiers

External IDs

OMIM: 601915 MGI: 109125 HomoloGene: 37748

Gene ontology
Molecular Function:	• enzyme inhibitor activity • metalloendopeptidase inhibitor activity
Cellular Component:	• extracellular region • proteinaceous extracellular matrix
Biological Process:	• biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003256 (mRNA)
NP_003247 (protein)

NM_080639 (mRNA)
NP_542370 (protein)

Location

Chr 3: 12.17 - 12.18 Mb

Chr 6: 115.21 - 115.22 Mb

Pubmed search

[1]

[2]

TIMP metallopeptidase inhibitor 4, also known as TIMP4, is a human gene.^[1]

This gene belongs to the tissue inhibitor of metalloproteinases gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling.^[1]

[edit] References

^ ^a ^b Entrez Gene: TIMP4 TIMP metallopeptidase inhibitor 4.

[edit] Further reading

Greene J, Wang M, Liu YE, et al. (1997). "Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4.". J. Biol. Chem. 271 (48): 30375–80. PMID 8939999.
Bigg HF, Shi YE, Liu YE, et al. (1997). "Specific, high affinity binding of tissue inhibitor of metalloproteinases-4 (TIMP-4) to the COOH-terminal hemopexin-like domain of human gelatinase A. TIMP-4 binds progelatinase A and the COOH-terminal domain in a similar manner to TIMP-2.". J. Biol. Chem. 272 (24): 15496–500. PMID 9182583.
Olson TM, Hirohata S, Ye J, et al. (1998). "Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively.". Genomics 51 (1): 148–51. doi:10.1006/geno.1998.5362. PMID 9693046.
Pohar N, Godenschwege TA, Buchner E (1999). "Invertebrate tissue inhibitor of metalloproteinase: structure and nested gene organization within the synapsin locus is conserved from Drosophila to human.". Genomics 57 (2): 293–6. doi:10.1006/geno.1999.5776. PMID 10198170.
Hernandez-Barrantes S, Shimura Y, Soloway PD, et al. (2001). "Differential roles of TIMP-4 and TIMP-2 in pro-MMP-2 activation by MT1-MMP.". Biochem. Biophys. Res. Commun. 281 (1): 126–30. doi:10.1006/bbrc.2001.4323. PMID 11178970.
Huang W, Li WQ, Dehnade F, Zafarullah M (2002). "Tissue inhibitor of metalloproteinases-4 (TIMP-4) gene expression is increased in human osteoarthritic femoral head cartilage.". J. Cell. Biochem. 85 (2): 295–303. PMID 11948685.
Zhang J, Cao YJ, Zhao YG, et al. (2003). "Expression of matrix metalloproteinase-26 and tissue inhibitor of metalloproteinase-4 in human normal cytotrophoblast cells and a choriocarcinoma cell line, JEG-3.". Mol. Hum. Reprod. 8 (7): 659–66. PMID 12087081.
Kai HS, Butler GS, Morrison CJ, et al. (2003). "Utilization of a novel recombinant myoglobin fusion protein expression system to characterize the tissue inhibitor of metalloproteinase (TIMP)-4 and TIMP-2 C-terminal domain and tails by mutagenesis. The importance of acidic residues in binding the MMP-2 hemopexin C-domain.". J. Biol. Chem. 277 (50): 48696–707. doi:10.1074/jbc.M209177200. PMID 12374789.
Radomski A, Jurasz P, Sanders EJ, et al. (2003). "Identification, regulation and role of tissue inhibitor of metalloproteinases-4 (TIMP-4) in human platelets.". Br. J. Pharmacol. 137 (8): 1330–8. doi:10.1038/sj.bjp.0704936. PMID 12466243.
Troeberg L, Tanaka M, Wait R, et al. (2003). "E. coli expression of TIMP-4 and comparative kinetic studies with TIMP-1 and TIMP-2: insights into the interactions of TIMPs and matrix metalloproteinase 2 (gelatinase A).". Biochemistry 41 (50): 15025–35. PMID 12475252.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Chegini N, Rhoton-Vlasak A, Williams RS (2003). "Expression of matrix metalloproteinase-26 and tissue inhibitor of matrix metalloproteinase-3 and -4 in endometrium throughout the normal menstrual cycle and alteration in users of levonorgestrel implants who experience irregular uterine bleeding.". Fertil. Steril. 80 (3): 564–70. PMID 12969699.
Zhao YG, Xiao AZ, Park HI, et al. (2004). "Endometase/matrilysin-2 in human breast ductal carcinoma in situ and its inhibition by tissue inhibitors of metalloproteinases-2 and -4: a putative role in the initiation of breast cancer invasion.". Cancer Res. 64 (2): 590–8. PMID 14744773.
Pilka R, Domanski H, Hansson S, et al. (2005). "Endometrial TIMP-4 mRNA is high at midcycle and in hyperplasia, but down-regulated in malignant tumours. Coordinated expression with MMP-26.". Mol. Hum. Reprod. 10 (9): 641–50. doi:10.1093/molehr/gah092. PMID 15273280.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Lee MH, Rapti M, Murphy G (2005). "Total conversion of tissue inhibitor of metalloproteinase (TIMP) for specific metalloproteinase targeting: fine-tuning TIMP-4 for optimal inhibition of tumor necrosis factor-{alpha}-converting enzyme.". J. Biol. Chem. 280 (16): 15967-75. doi:10.1074/jbc.M500897200. PMID 15713681.
Lizarraga F, Espinosa M, Maldonado V, Melendez-Zajgla J (2005). "Tissue inhibitor of metalloproteinases-4 is expressed in cervical cancer patients.". Anticancer Res. 25 (1B): 623–7. PMID 15816637.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Koskivirta I, Rahkonen O, Mäyränpää M, et al. (2007). "Tissue inhibitor of metalloproteinases 4 (TIMP4) is involved in inflammatory processes of human cardiovascular pathology.". Histochem. Cell Biol. 126 (3): 335–42. doi:10.1007/s00418-006-0163-8. PMID 16521002.
Pilka R, Noskova V, Domanski H, et al. (2006). "Endometrial TIMP-4 mRNA is expressed in the stroma, while TIMP-4 protein accumulates in the epithelium and is released to the uterine fluid.". Mol. Hum. Reprod. 12 (8): 497–503. doi:10.1093/molehr/gal055. PMID 16809379.