TIMP1

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TIMP metallopeptidase inhibitor 1
PDB rendering based on 1d2b.
Available structures: 1d2b, 1oo9, 1uea, 2j0t
Identifiers
Symbol(s)	TIMP1; EPO; CLGI; EPA; FLJ90373; HCI; TIMP
External IDs	OMIM: 305370 MGI: 98752 HomoloGene: 36321
Gene ontology Molecular Function: • enzyme inhibitor activity • protein binding • metalloendopeptidase inhibitor activity Cellular Component: • extracellular region • proteinaceous extracellular matrix • basement membrane Biological Process: • multicellular organismal development • positive regulation of cell proliferation • erythrocyte maturation • negative regulation of membrane protein ectodomain proteolysis
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	7076	21857
Ensembl	ENSG00000102265	ENSMUSG00000001131
Uniprot	P01033	Q6GXA9
Refseq	NM_003254 (mRNA) NP_003245 (protein)	NM_001044384 (mRNA) NP_001037849 (protein)
Location	Chr X: 47.33 - 47.33 Mb	Chr X: 20.03 - 20.03 Mb
Pubmed search	[1]	[2]

TIMP metallopeptidase inhibitor 1, also known as TIMP1, a tissue inhibitor of metalloproteinases, is a human gene.

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.^[1]

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