TIMM50

From Wikipedia, the free encyclopedia

Translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)

Identifiers

TIMM50; MGC102733; TIM50L

External IDs

OMIM: 607381 MGI: 1913775 HomoloGene: 57031

Gene ontology
Molecular Function:	• RNA binding • protein serine/threonine phosphatase activity • protein tyrosine phosphatase activity • protein binding • ribonucleoprotein binding
Cellular Component:	• nucleus • mitochondrion • mitochondrial inner membrane presequence translocase complex • membrane • integral to membrane • nuclear speck
Biological Process:	• protein amino acid dephosphorylation • protein targeting • mitochondrial membrane organization and biogenesis • protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001001563 (mRNA)
NP_001001563 (protein)

NM_025616 (mRNA)
NP_079892 (protein)

Location

Chr 19: 44.66 - 44.67 Mb

Chr 7: 28.01 - 28.02 Mb

Pubmed search

[1]

[2]

Translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae), also known as TIMM50, is a human gene.^[1]

[edit] References

^ Entrez Gene: TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae).

[edit] Further reading

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Xu H, Somers ZB, Robinson ML, Hebert MD (2006). "Tim50a, a nuclear isoform of the mitochondrial Tim50, interacts with proteins involved in snRNP biogenesis.". BMC Cell Biol. 6 (1): 29. doi:10.1186/1471-2121-6-29. PMID 16008839.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Guo Y, Cheong N, Zhang Z, et al. (2004). "Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death.". J. Biol. Chem. 279 (23): 24813-25. doi:10.1074/jbc.M402049200. PMID 15044455.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97-105. doi:10.1038/ncb1086. PMID 14743216.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Yuryev A, Wennogle LP (2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis.". Genomics 81 (2): 112-25. PMID 12620389.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Yamamoto H, Esaki M, Kanamori T, et al. (2002). "Tim50 is a subunit of the TIM23 complex that links protein translocation across the outer and inner mitochondrial membranes.". Cell 111 (4): 519-28. PMID 12437925.