Thymidine-triphosphatase

From Wikipedia, the free encyclopedia

In enzymology, a thymidine-triphosphatase (EC 3.6.1.39) is an enzyme that catalyzes the chemical reaction

dTTP + H₂O dTDP + phosphate

Thus, the two substrates of this enzyme are dTTP and H₂O, whereas its two products are dTDP and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is dTTP nucleotidohydrolase. Other names in common use include thymidine triphosphate nucleotidohydrolase, dTTPase, and deoxythymidine-5'-triphosphatase. This enzyme participates in pyrimidine metabolism.

[edit] References

• IUBMB entry for 3.6.1.39
• BRENDA references for 3.6.1.39 (Recommended.)
• PubMed references for 3.6.1.39
• PubMed Central references for 3.6.1.39
• Google Scholar references for 3.6.1.39
• Dahlmann N (1982). "Human serum thymidine triphosphate nucleotidohydrolase: purification and properties of a new enzyme". Biochemistry. 21: 6634–9. PMID 6297538. 

[edit] External links

The CAS registry number for this enzyme class is 37367-74-1.

• IUBMB entry for 3.6.1.39

• KEGG entry for 3.6.1.39

• BRENDA entry for 3.6.1.39

• NiceZyme view of 3.6.1.39

• EC2PDB: PDB structures for 3.6.1.39

• PRIAM entry for 3.6.1.39

• PUMA2 entry for 3.6.1.39

• IntEnz: Integrated Enzyme entry for 3.6.1.39

• MetaCyc entry for 3.6.1.39

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050339: thymidine-triphosphatase

• AMIGO entry for GO code 0050339: thymidine-triphosphatase