THOP1

From Wikipedia, the free encyclopedia

Thimet oligopeptidase 1

PDB rendering based on 1s4b.

Available structures: 1s4b, 2o36

Identifiers

Symbol(s)

THOP1; EP24.15; MEPD_HUMAN; MP78

External IDs

OMIM: 601117 MGI: 1354165 HomoloGene: 55726

Gene ontology
Molecular Function:	• metalloendopeptidase activity • protein binding • zinc ion binding • metal ion binding
Biological Process:	• proteolysis • peptide metabolic process • protein kinase cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_003249 (mRNA)
NP_003240 (protein)

NM_022653 (mRNA)
NP_073144 (protein)

Location

Chr 19: 2.74 - 2.76 Mb

Chr 10: 80.47 - 80.49 Mb

Pubmed search

[1]

[2]

Thimet oligopeptidase 1, also known as THOP1, is a human gene.^[1]

[edit] References

^ Entrez Gene: THOP1 thimet oligopeptidase 1.

[edit] Further reading

Thompson A, Huber G, Malherbe P (1995). "Cloning and functional expression of a metalloendopeptidase from human brain with the ability to cleave a beta-APP substrate peptide.". Biochem. Biophys. Res. Commun. 213 (1): 66-73. doi:10.1006/bbrc.1995.2099. PMID 7639763.
Papastoitsis G, Siman R, Scott R, Abraham CR (1994). "Identification of a metalloprotease from Alzheimer's disease brain able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.". Biochemistry 33 (1): 192-9. PMID 8286339.
Dando PM, Brown MA, Barrett AJ (1993). "Human thimet oligopeptidase.". Biochem. J. 294 ( Pt 2): 451-7. PMID 8373360.
Meckelein B, de Silva HA, Roses AD, et al. (1997). "Human endopeptidase (THOP1) is localized on chromosome 19 within the linkage region for the late-onset alzheimer disease AD2 locus.". Genomics 31 (2): 246-9. doi:10.1006/geno.1996.0041. PMID 8824811.
Torres MP, Prange C, Lennon G (1998). "Human endopeptidase 24.15 (THOP1) is localized on chromosome 19p13.3 and is excluded from the linkage region for late-onset Alzheimer disease.". Genomics 53 (2): 239-40. doi:10.1006/geno.1998.5487. PMID 9790774.
Crack PJ, Wu TJ, Cummins PM, et al. (1999). "The association of metalloendopeptidase EC 3.4.24.15 at the extracellular surface of the AtT-20 cell plasma membrane.". Brain Res. 835 (2): 113-24. PMID 10415366.
Pineau C, McCool S, Glucksman MJ, et al. (2000). "Distribution of thimet oligopeptidase (E.C. 3.4.24.15) in human and rat testes.". J. Cell. Sci. 112 ( Pt 20): 3455-62. PMID 10504294.
Ferro ES, Tullai JW, Glucksman MJ, Roberts JL (1999). "Secretion of metalloendopeptidase 24.15 (EC 3.4.24.15).". DNA Cell Biol. 18 (10): 781-9. doi:10.1089/104454999314926. PMID 10541437.
Tullai JW, Cummins PM, Pabon A, et al. (2001). "The neuropeptide processing enzyme EC 3.4.24.15 is modulated by protein kinase A phosphorylation.". J. Biol. Chem. 275 (47): 36514-22. doi:10.1074/jbc.M001843200. PMID 10969067.
Molina HM, Carmona AK, Kouyoumdjian M, Borges DR (2000). "Thimet oligopeptidase EC 3.4.24.15 is a major liver kininase.". Life Sci. 67 (5): 509-20. PMID 10993116.
Saric T, Beninga J, Graef CI, et al. (2001). "Major histocompatibility complex class I-presented antigenic peptides are degraded in cytosolic extracts primarily by thimet oligopeptidase.". J. Biol. Chem. 276 (39): 36474-81. doi:10.1074/jbc.M105517200. PMID 11479311.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gioli-Pereira L, Fontenele-Neto JD, Borges DR, Kouyoumdjian M (2003). "Localization of EP24.15, a major liver kininase.". J. Histochem. Cytochem. 51 (1): 125-7. PMID 12502762.
York IA, Mo AX, Lemerise K, et al. (2003). "The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation.". Immunity 18 (3): 429-40. PMID 12648459.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Ray K, Hines CS, Coll-Rodriguez J, Rodgers DW (2004). "Crystal structure of human thimet oligopeptidase provides insight into substrate recognition, regulation, and localization.". J. Biol. Chem. 279 (19): 20480-9. doi:10.1074/jbc.M400795200. PMID 14998993.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529-35. doi:10.1038/nature02399. PMID 15057824.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315-23. doi:10.1101/gr.2122004. PMID 15231747.
Saric T, Graef CI, Goldberg AL (2004). "Pathway for degradation of peptides generated by proteasomes: a key role for thimet oligopeptidase and other metallopeptidases.". J. Biol. Chem. 279 (45): 46723-32. doi:10.1074/jbc.M406537200. PMID 15328361.
Shivakumar BR, Wang Z, Hammond TG, Harris RC (2005). "EP24.15 interacts with the angiotensin II type I receptor and bradykinin B2 receptor.". Cell Biochem. Funct. 23 (3): 195-204. doi:10.1002/cbf.1176. PMID 15376229.